ChemInform Abstract: Highly Enantioselective Nucleophilic Dearomatization of Pyridines by Anion-Binding Catalysis

ChemInform Abstract: Highly Enantioselective Nucleophilic Dearomatization of Pyridines by Anion-Binding Catalysis

The one‐pot dearomatization of pyridines involves the in situ formation of N‐Troc pyridinium chloride salts followed by nucleophilic addition of ketene acetal (III) in the presence of chiral hydrogen donor catalyst (CTR).

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Veröffentlicht in:ChemInform 2015-11, Vol.46 (47), p.no-no
Hauptverfasser: Garcia Mancheno, Olga, Asmus, Soeren, Zurro, Mercedes, Fischer, Theresa
Format: Artikel
Sprache:eng
Schlagworte:
optical resolution
organocatalysis
pyridine derivatives
stereochemistry (general
stereochemistry (general, optical resolution)
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Beschreibung
Zusammenfassung:The one‐pot dearomatization of pyridines involves the in situ formation of N‐Troc pyridinium chloride salts followed by nucleophilic addition of ketene acetal (III) in the presence of chiral hydrogen donor catalyst (CTR).
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201547161