GW26-e2453 Beneficial Effect of Lycopene on Hypoxia/Reoxygenation-Induced Endoplasmic Reticulum Stress in Neonatal Mouse Cardiomyocytes

GW26-e2453 Beneficial Effect of Lycopene on Hypoxia/Reoxygenation-Induced Endoplasmic Reticulum Stress in Neonatal Mouse Cardiomyocytes

Conclusions The present study demonstrated that lycopene protects primary cultured neonatal mouse cardiomyocytes against H/R injury by inhibiting the activation of the PERK and the IRE1 pathway of the ER stress, the protective effect of lycopene on cardiomyocytes highlights the therapeutic potential...

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Veröffentlicht in:Journal of the American College of Cardiology 2015-10, Vol.66 (16), p.C35-C35
Hauptverfasser: Xu, Jiqian, Hu, Houxiang, Chen, Bin, Yue, Rongchuan, Zhou, Zhou, Xu, Lei, Zhang, Shuang, Tan, Chunyan, Yu, Zhengping
Format: Artikel
Sprache:eng
Schlagworte:
Cardiology
Cardiomyocytes
Cardiovascular
Endoplasmic reticulum
Hypoxia
Internal Medicine
Rodents
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Zusammenfassung:Conclusions The present study demonstrated that lycopene protects primary cultured neonatal mouse cardiomyocytes against H/R injury by inhibiting the activation of the PERK and the IRE1 pathway of the ER stress, the protective effect of lycopene on cardiomyocytes highlights the therapeutic potential of plant-derived antioxidants against I/R-injury.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2015.06.1161