Formulation and In-vitro Evaluation of Fast Dissolving Tablets Using Pregabalin as a Model Drug

Pregabalin is used for treating pain caused by neurologic diseases such as neuralgias as well as seizures. In the present work, fast dissolving tablets of Pregabalin were prepared by direct compression method with a view to enhance patient compliance, for the treatment of epilepsy. Fast dissolving tablets were disintegrated in the mouth and were dissolved within a matter of few seconds without need of water. Fast dissolving tablets (FDTs) were prepared using different concentration of superdisintegrants and evaluated for the pre-compression parameters. The prepared tablets were evaluated for post compressional evaluation. It was observed that wetting time of formulations containing Crospovidone was least and tablets showed fastest disintegration. The drug release from fast dissolving tablets (FDTs) increased with increasing concentration of superdisintegrants and was found to be highest with formulations containing Crospovidone.