GW26-e0255 Targeted down-regulation of cardiac CD36 by lentivirus-mediated RNA interference prevents cardiac hypertrophy and systolic dysfunction in high-fat-diet induced obese mice

GW26-e0255 Targeted down-regulation of cardiac CD36 by lentivirus-mediated RNA interference prevents cardiac hypertrophy and systolic dysfunction in high-fat-diet induced obese mice

Inhibition of cardiac CD36 also mitigated obesity induced alteration in BUN, creatinine and triglyceride, but had no effect on FSG or TC. [...]cardiospecific CD36 deficiency corrected myocardial lipid overaccumulation and intracellular ROS overproduction that were induced by HFD feeding.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of the American College of Cardiology 2015-10, Vol.66 (16), p.C130-C130
Hauptverfasser: Zhang, Yijie, Dai, Mingyan, Bao, Mingwei
Format: Artikel
Sprache:eng
Schlagworte:
Cardiology
Cardiomyopathy
Cardiovascular
Internal Medicine
Morphology
Obesity
Rodents
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Zusammenfassung:Inhibition of cardiac CD36 also mitigated obesity induced alteration in BUN, creatinine and triglyceride, but had no effect on FSG or TC. [...]cardiospecific CD36 deficiency corrected myocardial lipid overaccumulation and intracellular ROS overproduction that were induced by HFD feeding.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2015.06.501