GW26-e0721 Macrophage Migration Inhibitory Factor (MIF) Promotes the Expression of GLUT4 Glucose Transporter Through MEF2 and Zac1 in Cardiomyocytes

GW26-e0721 Macrophage Migration Inhibitory Factor (MIF) Promotes the Expression of GLUT4 Glucose Transporter Through MEF2 and Zac1 in Cardiomyocytes

Knockdown of MEF2A, -2C, -2D and Zac1 could significantly inhibit glucose uptake and GLUT4 expression in cardiomyocytes. [...]EMSA results revealed that transcriptional activities of MEF2 and Zac1 were significantly increased in MIF-treated NMVCs.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of the American College of Cardiology 2015-10, Vol.66 (16), p.C7-C8
Hauptverfasser: Shan, Zhixin, Wu, Shulin
Format: Artikel
Sprache:eng
Schlagworte:
Cardiology
Cardiomyocytes
Cardiovascular
Diabetes
Genes
Glucose
Internal Medicine
Transcription factors
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Zusammenfassung:Knockdown of MEF2A, -2C, -2D and Zac1 could significantly inhibit glucose uptake and GLUT4 expression in cardiomyocytes. [...]EMSA results revealed that transcriptional activities of MEF2 and Zac1 were significantly increased in MIF-treated NMVCs.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2015.06.053