GW26-e1388 Transplantation of EPCs Overexpressing S1PR3 Promotes Vascular Repair in the Early Phase After Vascular Injury

GW26-e1388 Transplantation of EPCs Overexpressing S1PR3 Promotes Vascular Repair in the Early Phase After Vascular Injury

Conclusions Our data suggest that transplantation of EPCs overexpressing S1PR3 can have a combined effect of both amplifying the reendothelialization capacity of EPCs and inhibiting neointima formation so as to facilitate better inhibition of adverse remodeling after vascular injury. [...]gene modif...

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Veröffentlicht in:Journal of the American College of Cardiology 2015-10, Vol.66 (16), p.C31-C31
Hauptverfasser: Wang, Hang, Cai, Keyin, Wang, Li, Zhao, Kehong, Tu, Ying, Wang, Xiao, Li, Jiahuan, Huang, Hao
Format: Artikel
Sprache:eng
Schlagworte:
Angioplasty
Cardiology
Cardiovascular
Carotid arteries
Internal Medicine
Veins & arteries
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Zusammenfassung:Conclusions Our data suggest that transplantation of EPCs overexpressing S1PR3 can have a combined effect of both amplifying the reendothelialization capacity of EPCs and inhibiting neointima formation so as to facilitate better inhibition of adverse remodeling after vascular injury. [...]gene modified EPCs may be applied in clinical progenitor cell therapy to improve vascular repair after vascular injury.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2015.06.1144