Chemokine receptors CCR5 and CCR2 genes in HIV positive, HIV exposed seronegative and in HIV unexposed individuals: A study from Mumbai

Sir, Discordant couples are a group of individuals who are considered as a good model to evaluate the association of different host factors with human immunodeficiency virus (HIV) transmission. [...]a prospective case control study was conducted during the years 2008-2011 with approval of the Institutional Ethics Committee and Hospital Ethics Committee to evaluate (i) these mutations among the western Indian population in Mumbai; (ii) the frequency of CCR5[Delta]32 and viral load with HIV transmission among sero-discordant couples and (iii) CCR2 V64I polymorphism frequency and its association with delay in disease progression among the HIV infected spouse.