Diagnostic accuracy of ^sup 18^F-FDG PET/CT compared with that of contrast-enhanced MRI of the breast at 3 T

Purpose To compare the diagnostic accuracy of prone ^sup 18^F-FDG PET/CT with that of contrast-enhanced MRI (CE-MRI) at 3 T in suspicious breast lesions. To evaluate the influence of tumour size on diagnostic accuracy and the use of maximum standardized uptake value (SUV^sub MAX^) thresholds to differentiate malignant from benign breast lesions. Methods A total of 172 consecutive patients with an imaging abnormality were included in this IRB-approved prospective study. All patients underwent ^sup 18^F-FDG PET/CT and CE-MRI of the breast at 3 T in the prone position. Two reader teams independently evaluated the likelihood of malignancy as determined by ^sup 18^F-FDG PET/CT and CE-MRI independently. ^sup 18^F-FDG PET/CT data were qualitatively evaluated by visual interpretation. Quantitative assessment was performed by calculation of SUV^sub MAX^. Sensitivity, specificity, diagnostic accuracy, area under the curve and interreader agreement were calculated for all lesions and for lesions