ChemInform Abstract: Asymmetric One-Pot Synthesis of 1,4-Dihydroquinolines via an Organocatalytic Aza-Michael/Michael Cascade Strategy

The asymmetric aza‐Michael/Michael cascade reaction of 2‐(tosylamino)phenyl substituted α,β‐unsaturated ketones with arylpropionaldehydes is optimized using a catalyst combination of O‐Tms‐diphenylprolinol and o‐nitrobenzoic acid.

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Bibliographische Detailangaben
Veröffentlicht in:	ChemInform 2015-09, Vol.46 (36), p.no-no
Hauptverfasser:	Lee, Yona, Heo, Seungpyeong, Kim, Sung-Gon
Format:	Artikel
Sprache:	eng
Schlagworte:	annulation reactions cascade reactions cascade reactions, domino reactions, tandem reactions diastereoselective syntheses diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism) domino reactions enantioselective syntheses (incl. cis/trans-isomerism) organocatalysis quinoline derivatives ring closure reactions ring closure reactions, annulation reactions tandem reactions
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Beschreibung
Zusammenfassung:	The asymmetric aza‐Michael/Michael cascade reaction of 2‐(tosylamino)phenyl substituted α,β‐unsaturated ketones with arylpropionaldehydes is optimized using a catalyst combination of O‐Tms‐diphenylprolinol and o‐nitrobenzoic acid.
ISSN:	0931-7597 1522-2667
DOI:	10.1002/chin.201536181