Effect of Intensive Statin Therapy on Coronary High-Intensity Plaques Detected by Noncontrast T1-Weighted Imaging

Abstract Background Coronary high-intensity plaques detected by noncontrast T1-weighted imaging may represent plaque instability. High-intensity plaques can be quantitatively assessed by a plaque-to-myocardium signal-intensity ratio (PMR). Objectives This pilot, hypothesis-generating study sought to...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American College of Cardiology 2015-07, Vol.66 (3), p.245-256
Hauptverfasser:	Noguchi, Teruo, MD, Tanaka, Atsushi, MD, Kawasaki, Tomohiro, MD, Goto, Yoichi, MD, Morita, Yoshiaki, MD, Asaumi, Yasuhide, MD, Nakao, Kazuhiro, MD, Fujiwara, Reiko, MD, Nishimura, Kunihiro, MD, Miyamoto, Yoshihiro, MD, Ishihara, Masaharu, MD, Ogawa, Hisao, MD, Koga, Nobuhiko, MD, Narula, Jagat, MD, PhD, Yasuda, Satoshi, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Angina pectoris atherosclerosis cardiac magnetic resonance Cardiology Cardiovascular Cholesterol coronary artery disease Heart attacks Internal Medicine Medical imaging Statins vulnerable plaque
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract Background Coronary high-intensity plaques detected by noncontrast T1-weighted imaging may represent plaque instability. High-intensity plaques can be quantitatively assessed by a plaque-to-myocardium signal-intensity ratio (PMR). Objectives This pilot, hypothesis-generating study sought to investigate whether intensive statin therapy would lower PMR. Methods Prospective serial noncontrast T1-weighted magnetic resonance imaging and computed tomography angiography were performed in 48 patients with coronary artery disease at baseline and after 12 months of intensive pitavastatin treatment with a target low-density lipoprotein cholesterol level
ISSN:	0735-1097 1558-3597
DOI:	10.1016/j.jacc.2015.05.056