The Nugent Reagent: A Formidable Tool in Contemporary Radical and Organometallic Chemistry

The vast range of reactions mediated by titanocene monochloride (Cp2TiCl, the Nugent reagent) in organic synthetic chemistry is reviewed. The power of the Nugent reagent in organic chemistry is demonstrated by its ability to promote and/or catalyse several efficient transformations under mild reaction conditions in the presence of several functional groups, in an environmentally friendly manner and with use of simple experimental procedures. The different reactions promoted and/or catalysed by the Nugent reagent, a contemporary single‐electron transfer agent, are reported. The combination of radical intermediates and transition‐metal catalysis is an excellent tool for the development of new and efficient synthetic procedures.