A prostate cancer-targeted polyarginine-disulfide linked PEI nanocarrier for delivery of microRNA
Highlights • The R11-nanomaterials could specifically deliver miR-145 to prostate cancer. • The functional action of miR-145 oligomers can be released from polyplexes. • The R11-nanomaterials could dramatically inhibit tumor growth and prolonged survival time.
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| Veröffentlicht in: | Cancer letters 2015-09, Vol.365 (2), p.156-165 |
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| container_end_page | 165 |
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| container_issue | 2 |
| container_start_page | 156 |
| container_title | Cancer letters |
| container_volume | 365 |
| creator | Zhang, Tingting Xue, Xiang He, Dalin Hsieh, Jer-Tsong |
| description | Highlights • The R11-nanomaterials could specifically deliver miR-145 to prostate cancer. • The functional action of miR-145 oligomers can be released from polyplexes. • The R11-nanomaterials could dramatically inhibit tumor growth and prolonged survival time. |
| doi_str_mv | 10.1016/j.canlet.2015.05.003 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Cancer letters, 2015-09, Vol.365 (2), p.156-165 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biocompatibility Biomarkers, Tumor - genetics Cancer therapies Cell growth Cell Line, Tumor Drug Carriers - therapeutic use Gene therapy Genetic Therapy - methods Genetic Vectors Hematology, Oncology and Palliative Medicine Humans Male Mice MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - therapeutic use Nanoparticles Nanoparticles - therapeutic use Peptides Peptides - therapeutic use Peritoneal Neoplasms - drug therapy Polyethylene glycol Polyplex Prostate cancer Prostatic Neoplasms - drug therapy R11 peptide Studies Transfection Tumors |
| title | A prostate cancer-targeted polyarginine-disulfide linked PEI nanocarrier for delivery of microRNA |
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