A prostate cancer-targeted polyarginine-disulfide linked PEI nanocarrier for delivery of microRNA

Highlights • The R11-nanomaterials could specifically deliver miR-145 to prostate cancer. • The functional action of miR-145 oligomers can be released from polyplexes. • The R11-nanomaterials could dramatically inhibit tumor growth and prolonged survival time.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2015-09, Vol.365 (2), p.156-165
Hauptverfasser:	Zhang, Tingting, Xue, Xiang, He, Dalin, Hsieh, Jer-Tsong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatibility Biomarkers, Tumor - genetics Cancer therapies Cell growth Cell Line, Tumor Drug Carriers - therapeutic use Gene therapy Genetic Therapy - methods Genetic Vectors Hematology, Oncology and Palliative Medicine Humans Male Mice MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - therapeutic use Nanoparticles Nanoparticles - therapeutic use Peptides Peptides - therapeutic use Peritoneal Neoplasms - drug therapy Polyethylene glycol Polyplex Prostate cancer Prostatic Neoplasms - drug therapy R11 peptide Studies Transfection Tumors
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Beschreibung
Zusammenfassung:	Highlights • The R11-nanomaterials could specifically deliver miR-145 to prostate cancer. • The functional action of miR-145 oligomers can be released from polyplexes. • The R11-nanomaterials could dramatically inhibit tumor growth and prolonged survival time.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2015.05.003