An in silico model of aspirin-iduced inactivation of platelet and Megakaryocyte Cyclooxygenase-1

An in silico model of aspirin-iduced inactivation of platelet and Megakaryocyte Cyclooxygenase-1

[...]the model explains an increased COX-1 acetylation following a shorter dosing interval (100 mg twice daily) as compared to a higher (200 mg) once-daily dose in ET patients.

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Veröffentlicht in:Clinical therapeutics 2015-08, Vol.37 (8), p.e7-e7
Hauptverfasser: Giaretta, A, Rocca, B, Di Camillo, B, Toffolo, G.M, Patrono, C
Format: Artikel
Sprache:eng
Schlagworte:
Aspirin
Internal Medicine
Mathematical models
Medical Education
Sensitivity analysis
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Beschreibung
Zusammenfassung:[...]the model explains an increased COX-1 acetylation following a shorter dosing interval (100 mg twice daily) as compared to a higher (200 mg) once-daily dose in ET patients.
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2015.05.030