Carboxylesterase 1 C.428G>A single nucleotide variation reduces hydrolysis of clopidogrel and enalapril, but not that of Quinapril

Carboxylesterase 1 C.428G>A single nucleotide variation reduces hydrolysis of clopidogrel and enalapril, but not that of Quinapril

Conclusions The CES1 c.428G>A SNV increased clopidogrel active metabolite concentrations and antiplatelet effects by reducing hydrolysis of parent clopidogrel to inactive metabolites. [...]the CES1 c.428A allele may increase clopidogrel efficacy and bleeding risk.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Clinical therapeutics 2015-08, Vol.37 (8), p.e3-e3
Hauptverfasser: Tarkiainen, E.K, Holmberg, M.T, Tornio, A, Neuvonen, M, Launiainen, T, Neuvonen, P.J, Backman, J.T, Niemi, M
Format: Artikel
Sprache:eng
Schlagworte:
Internal Medicine
Medical Education
Metabolites
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Conclusions The CES1 c.428G>A SNV increased clopidogrel active metabolite concentrations and antiplatelet effects by reducing hydrolysis of parent clopidogrel to inactive metabolites. [...]the CES1 c.428A allele may increase clopidogrel efficacy and bleeding risk.
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2015.05.018