Iron-Catalysed Oxidative Ugi-Type Multicomponent Reaction Using (Arylmethyl)amines as Imine Precursors

Iron-Catalysed Oxidative Ugi-Type Multicomponent Reaction Using (Arylmethyl)amines as Imine Precursors

An efficient iron‐catalysed Ugi‐type three‐component reaction involving oxidation of (arylmethyl)amines to imines directly under air as a safe oxidant is reported. The reaction is executed as a one‐step procedure, and has a broad substrate scope with respect to all components. The oxidative three‐co...

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Veröffentlicht in:European journal of organic chemistry 2015-07, Vol.2015 (19), p.4238-4245
Hauptverfasser: Dighe, Shashikant U., Kolle, Shivalinga, Batra, Sanjay
Format: Artikel
Sprache:eng
Schlagworte:
Homogeneous catalysis
Iron
Multicomponent reactions
Oxidation
Oxygen
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Zusammenfassung:An efficient iron‐catalysed Ugi‐type three‐component reaction involving oxidation of (arylmethyl)amines to imines directly under air as a safe oxidant is reported. The reaction is executed as a one‐step procedure, and has a broad substrate scope with respect to all components. The oxidative three‐component Ugi reaction catalysed by Fe(NO3)3·9H2O using (arylmethyl)amine as the imine source under aerobic conditions is described.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201500464