Peptide-Catalyzed Desymmetrization of an Achiral Ferrocenyl Compound To Induce Planar Chirality

Selective monohydrogenation of an achiral ferrocenebis(enal) was achieved with a resin‐supported peptide catalyst to afford an enantioenriched planar‐chiral product. It was also demonstrated that the reaction was followed by a kinetic resolution through cyclization of the product. Planar chirality was induced on an achiral ferrocenyl compound by peptide‐catalyzed desymmetrization. Although such an asymmetric reaction could not be realized with a low‐molecular‐weight catalyst, a resin‐supported peptide with a turn structure afforded products in a highly enantioselective manner.