ChemInform Abstract: A Complementary Route to Diaminopyrimidines Through Regioselective SNAr Amination Reactions

ChemInform Abstract: A Complementary Route to Diaminopyrimidines Through Regioselective SNAr Amination Reactions

2‐Chloro‐4‐(2,3,5,6‐tetrafluorophenoxy)pyrimidine (I) can be diaminated in a regioselective stepwise manner: first amination occurs at C‐2, second amination at C‐4.

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Bibliographische Detailangaben
Veröffentlicht in:ChemInform 2015-07, Vol.46 (27), p.no-no
Hauptverfasser: O'Donnell, Michael, Charrier, Jean-Damien
Format: Artikel
Sprache:eng
Schlagworte:
amination
amination, N‐alkylation, N‐arylation
amines (acyclic compounds)
amines (benzene compounds)
N-alkylation
N-arylation
pyrimidine derivatives
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Zusammenfassung:2‐Chloro‐4‐(2,3,5,6‐tetrafluorophenoxy)pyrimidine (I) can be diaminated in a regioselective stepwise manner: first amination occurs at C‐2, second amination at C‐4.
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201527219