A novel evaluation system to monitor bone formation and [beta]-tricalcium phosphate resorption in opening wedge high tibial osteotomy

The aim of this study was to establish an evaluation system to monitor bone formation and beta-tricalcium phosphate (TCP) resorption in opening high tibial osteotomy (HTO). From 2003 to 2005, opening HTO was performed in 36 patients using a Puddu plate and [beta]-TCP blocks with 60 and 75 % porosity. Thirty-one patients were used for evaluation. All patients underwent CT examination at 2 weeks and 6 years. The CT image data were divided into three areas, and CT values of each area were analysed using the imaging software, Osirix. CT image analysis at 2 weeks showed that the mean CT-attenuation values (in Hounsfield units) of the implanted area with [beta]-TCP of 60 % porosity, the implanted area with [beta]-TCP of 75 % porosity, and cancellous bone were, 1,694.0 ± 94.2, 1,010.9 ± 81.1, and 178.0 ± 45.1, respectively. Six years after surgery, these values were 574.1 ± 273.5, 168.8 ± 75.1, and 174.9 ± 69.3, respectively. [beta]-TCP with 75 % porosity was completely resorbed and replaced by bone. [beta]-TCP with 60 % porosity was resorbed, but approximately 1/3 still remained even 6 years after surgery. The imaging software, Osirix, enabled scanning of the whole area to measure CT values. This system is the first to quantitatively evaluate [beta]-TCP resorption and bone formation in opening HTO. Laboratory studies.