New Casbane Diterpenoids from the Hainan Soft Coral Sinularia Species

New Casbane Diterpenoids from the Hainan Soft Coral Sinularia Species

Six new casbane diterpenoids, sinularcasbanes G–L (1–6, resp.) were isolated from the soft coral Sinularia sp. Their structures were established by extensive spectroscopic analyses, especially 2D‐NMR and HR‐ESI‐MS. The configuration was confirmed by CD analyses and by comparison with data reported i...

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Veröffentlicht in:Helvetica chimica acta 2015-06, Vol.98 (6), p.834-841
Hauptverfasser: Yang, Bin, Huang, Jingxia, Lin, Xiuping, Liao, Shengrong, Zhou, Xuefeng, Liu, Juan, Wang, Junfeng, Wang, Lishu, Liu, Yonghong
Format: Artikel
Sprache:eng
Schlagworte:
Casbane diterpenoids
Cytotoxic activity
Sinularia
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Zusammenfassung:Six new casbane diterpenoids, sinularcasbanes G–L (1–6, resp.) were isolated from the soft coral Sinularia sp. Their structures were established by extensive spectroscopic analyses, especially 2D‐NMR and HR‐ESI‐MS. The configuration was confirmed by CD analyses and by comparison with data reported in the literature. The compounds were evaluated for cytotoxicity against ten human cancer cell lines (H1975, U937, K562, BGC823, MOLT‐4, MCF‐7, A549, HeLa, HL60, and Huh‐7) and showed no activity.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201400341