Synthesis of a P-Stereogenic PNPtBu,Ph Ruthenium Pincer Complex and Its Application in Asymmetric Reduction of Ketones

Synthesis of a P-Stereogenic PNPtBu,Ph Ruthenium Pincer Complex and Its Application in Asymmetric Reduction of Ketones

A novel P‐stereogenic PNPtBu,Ph ruthenium complex has been synthesized and characterized enabling the asymmetric hydrogenation of a wide range of aromatic ketones with excellent catalytic activities (up to 98 % conversion) and good levels of enantiodiscrimination (up to 95 % ee). P‐stereogenic PNPtB...

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Veröffentlicht in:European journal of organic chemistry 2015-06, Vol.2015 (17), p.3666-3669
Hauptverfasser: Arenas, Ismael, Boutureira, Omar, Matheu, M. Isabel, Díaz, Yolanda, Castillón, Sergio
Format: Artikel
Sprache:eng
Schlagworte:
Asymmetric hydrogenation
Chiral alcohols
Pincer ligands
Ruthenium
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Zusammenfassung:A novel P‐stereogenic PNPtBu,Ph ruthenium complex has been synthesized and characterized enabling the asymmetric hydrogenation of a wide range of aromatic ketones with excellent catalytic activities (up to 98 % conversion) and good levels of enantiodiscrimination (up to 95 % ee). P‐stereogenic PNPtBu,Ph Ru complex was for the first time synthesized and characterized and has proven to be an efficient catalyst for the asymmetric reduction of a wide range of ketones
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201500389