In Vitro and In Vivo Miltefosine Susceptibility of a Leishmania amazonensis Isolate from a Patient with Diffuse Cutaneous Leishmaniasis: e2999

L. amazonensis is also the etiological agent of diffuse cutaneous leishmaniasis (DCL), a severe pathology associated with defective cell mediated immune responses to the parasite [3]. Since there is no effective vaccine for prevention, control is essentially based on chemotherapy. MF resistance in Leishmania is mainly due to a drastic reduction in drug accumulation [9], associated with the inactivation of a P-type ATPase, also known as Miltefosine Transporter (MT), responsible for the translocation of phospholipids across the plasma membrane of the parasite [10]. MF susceptibility data for L.\n These findings highlight the need to consider in vitro resistance determinations with caution as well as the relevance of MT as a potential molecular marker of MF unresponsiveness in leishmaniasis patients.