ANALGESIC AND ANXIOLYTIC EVALUATION OF N'-SUBSTITUTED ARYLSULPHONYL AND BENZOYL DERIVATIVES OF 4-PYRIDINE CARBOHYDRAZIDE

4-Pyridine carbohydrazide (4-PCH) and its synthetic derivatives divulged an array of pharmacological activities. In continuation of our search for development of new potent and effective drug candidates, this study was aimed to investigate the previously synthesized N'-substituted arylsulphonyl and benzoyl derivatives of PCH for analgesic and anxiolytic effects by known experimental protocols. It was found that only N'-[(4-methylbenzene) sulfonyl]pyridine-4-carbohydrazide (1) exhibited analgesia at the dose of 25 mg/Kg body weight in tail flick test. In open field test (OFT), it was observed that N'-[(4-bromobenzene)sulfonyl]pyridine-4-carbohydrazide (3), N'-[(4-nitrobenzene)sulfonyl]pyridme-4-carbohydrazide (4) and N'-[4-methylbenzoyl) ]pyridine-4-carbohydrazide (5) showed anxiolytic like behavior. Structure Activity Relationship (SAR) was also ascertained.