Transcatheter Mitral Valve Replacement for the Treatment of Mitral Regurgitation

Patient 1 had twice undergone coronary artery bypass graft operations and presented with severe functional MR. Patient 2 also had previously undergone coronary artery bypass grafting and presented with significant renal impairment and severe degenerative MR. Patient 3 was a frail elderly man with severe degenerative MR. All had >1 hospital admission with overt heart failure in the 6 months before their implantation. Patient #1 Patient #2 Patient #3 Age, yrs 68 75 87 Sex Female Male Male Pre-TMVR NYHA functional class IV IV III Glomerular filtration rate, ml/min 47 18 44 Previous CABG Yes Yes No Heart failure hospital admission in previous 6 months 2 1 1 Etiology MR Secondary Primary Primary Pre-TMVR MR grade (EROA, cm2) 0.34 0.79 1.39 Post-TMVR MR grade None Trivial None Post-TMVR peak/mean mitral gradient, mm Hg 8/3 11/5 7/2 Length of hospital stay, days 20 7 5 Discharge destination Home Home Home Table 1 Patient Profiles CABG = coronary artery bypass grafting; EROA = effective regurgitant orifice area; MR = mitral regurgitation; NHYA = New York Heart Association; TMVR = transmitral valve replacement.