Risk Neurogenes for Long-Term Spaceflight: Dopamine and Serotonin Brain System

Mice were exposed to 1 month of spaceflight on Russian biosatellite BION-M1 to determine its effect on the expression of key genes in the brain dopamine (DA) and serotonin (5-HT) systems. Spaceflight decreased the expression of crucial genes involved in DA synthesis and degradation, as well as the D...

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Veröffentlicht in:Molecular neurobiology 2015-06, Vol.51 (3), p.1443-1451
Hauptverfasser: Popova, N. K., Kulikov, A. V., Kondaurova, E. M., Tsybko, A. S., Kulikova, E. A., Krasnov, I. B., Shenkman, B. S., Bazhenova, E. Yu, Sinyakova, N. A., Naumenko, V. S.
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container_end_page 1451
container_issue 3
container_start_page 1443
container_title Molecular neurobiology
container_volume 51
creator Popova, N. K.
Kulikov, A. V.
Kondaurova, E. M.
Tsybko, A. S.
Kulikova, E. A.
Krasnov, I. B.
Shenkman, B. S.
Bazhenova, E. Yu
Sinyakova, N. A.
Naumenko, V. S.
description Mice were exposed to 1 month of spaceflight on Russian biosatellite BION-M1 to determine its effect on the expression of key genes in the brain dopamine (DA) and serotonin (5-HT) systems. Spaceflight decreased the expression of crucial genes involved in DA synthesis and degradation, as well as the D1 receptor. However, spaceflight failed to alter the expression of tryptophan hydroxylase-2, 5-HT transporter, 5-HT 1A , and 5-HT 3 receptor genes, though it reduced 5-HT 2A receptor gene expression in the hypothalamus. We revealed risk DA and 5-HT neurogenes for long-term spaceflight for the first time, as well as microgravity-responsive genes (tyrosine hydroxylase, catechol-O-methyltransferase, and D1 receptor in the nigrostriatal system; D1 and 5-HT 2A receptors in the hypothalamus; and monoamine oxidase A (MAO A) in the frontal cortex). Decreased genetic control of the DA system may contribute to the spaceflight-induced locomotor impairment and dyskinesia described for both humans and rats.
doi_str_mv 10.1007/s12035-014-8821-7
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subjects Animals
Behavior, Animal - physiology
Biomedical and Life Sciences
Biomedicine
Brain
Brain - metabolism
Cell Biology
Dopamine
Dopamine - metabolism
Gene expression
Gene Expression Regulation - physiology
Humans
Male
Mice, Inbred C57BL
Neurobiology
Neurology
Neurosciences
Receptor, Serotonin, 5-HT2A - metabolism
Rodents
Serotonin
Serotonin - metabolism
Space Flight
Spacecraft
Stress
Time
Weightlessness
title Risk Neurogenes for Long-Term Spaceflight: Dopamine and Serotonin Brain System
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