Risk Neurogenes for Long-Term Spaceflight: Dopamine and Serotonin Brain System
Mice were exposed to 1 month of spaceflight on Russian biosatellite BION-M1 to determine its effect on the expression of key genes in the brain dopamine (DA) and serotonin (5-HT) systems. Spaceflight decreased the expression of crucial genes involved in DA synthesis and degradation, as well as the D...
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creator | Popova, N. K. Kulikov, A. V. Kondaurova, E. M. Tsybko, A. S. Kulikova, E. A. Krasnov, I. B. Shenkman, B. S. Bazhenova, E. Yu Sinyakova, N. A. Naumenko, V. S. |
description | Mice were exposed to 1 month of spaceflight on Russian biosatellite BION-M1 to determine its effect on the expression of key genes in the brain dopamine (DA) and serotonin (5-HT) systems. Spaceflight decreased the expression of crucial genes involved in DA synthesis and degradation, as well as the D1 receptor. However, spaceflight failed to alter the expression of tryptophan hydroxylase-2, 5-HT transporter, 5-HT
1A
, and 5-HT
3
receptor genes, though it reduced 5-HT
2A
receptor gene expression in the hypothalamus. We revealed risk DA and 5-HT neurogenes for long-term spaceflight for the first time, as well as microgravity-responsive genes (tyrosine hydroxylase, catechol-O-methyltransferase, and D1 receptor in the nigrostriatal system; D1 and 5-HT
2A
receptors in the hypothalamus; and monoamine oxidase A (MAO A) in the frontal cortex). Decreased genetic control of the DA system may contribute to the spaceflight-induced locomotor impairment and dyskinesia described for both humans and rats. |
doi_str_mv | 10.1007/s12035-014-8821-7 |
format | Article |
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1A
, and 5-HT
3
receptor genes, though it reduced 5-HT
2A
receptor gene expression in the hypothalamus. We revealed risk DA and 5-HT neurogenes for long-term spaceflight for the first time, as well as microgravity-responsive genes (tyrosine hydroxylase, catechol-O-methyltransferase, and D1 receptor in the nigrostriatal system; D1 and 5-HT
2A
receptors in the hypothalamus; and monoamine oxidase A (MAO A) in the frontal cortex). Decreased genetic control of the DA system may contribute to the spaceflight-induced locomotor impairment and dyskinesia described for both humans and rats.</description><identifier>ISSN: 0893-7648</identifier><identifier>EISSN: 1559-1182</identifier><identifier>DOI: 10.1007/s12035-014-8821-7</identifier><identifier>PMID: 25084757</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Behavior, Animal - physiology ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Brain - metabolism ; Cell Biology ; Dopamine ; Dopamine - metabolism ; Gene expression ; Gene Expression Regulation - physiology ; Humans ; Male ; Mice, Inbred C57BL ; Neurobiology ; Neurology ; Neurosciences ; Receptor, Serotonin, 5-HT2A - metabolism ; Rodents ; Serotonin ; Serotonin - metabolism ; Space Flight ; Spacecraft ; Stress ; Time ; Weightlessness</subject><ispartof>Molecular neurobiology, 2015-06, Vol.51 (3), p.1443-1451</ispartof><rights>Springer Science+Business Media New York 2014</rights><rights>Springer Science+Business Media New York 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p179t-c924ae0e53f5a66ea025606cb216ce34341dee970556c878b5e9b5218ca9ff7c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12035-014-8821-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12035-014-8821-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25084757$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Popova, N. K.</creatorcontrib><creatorcontrib>Kulikov, A. V.</creatorcontrib><creatorcontrib>Kondaurova, E. M.</creatorcontrib><creatorcontrib>Tsybko, A. S.</creatorcontrib><creatorcontrib>Kulikova, E. A.</creatorcontrib><creatorcontrib>Krasnov, I. B.</creatorcontrib><creatorcontrib>Shenkman, B. S.</creatorcontrib><creatorcontrib>Bazhenova, E. Yu</creatorcontrib><creatorcontrib>Sinyakova, N. A.</creatorcontrib><creatorcontrib>Naumenko, V. S.</creatorcontrib><title>Risk Neurogenes for Long-Term Spaceflight: Dopamine and Serotonin Brain System</title><title>Molecular neurobiology</title><addtitle>Mol Neurobiol</addtitle><addtitle>Mol Neurobiol</addtitle><description>Mice were exposed to 1 month of spaceflight on Russian biosatellite BION-M1 to determine its effect on the expression of key genes in the brain dopamine (DA) and serotonin (5-HT) systems. Spaceflight decreased the expression of crucial genes involved in DA synthesis and degradation, as well as the D1 receptor. However, spaceflight failed to alter the expression of tryptophan hydroxylase-2, 5-HT transporter, 5-HT
1A
, and 5-HT
3
receptor genes, though it reduced 5-HT
2A
receptor gene expression in the hypothalamus. We revealed risk DA and 5-HT neurogenes for long-term spaceflight for the first time, as well as microgravity-responsive genes (tyrosine hydroxylase, catechol-O-methyltransferase, and D1 receptor in the nigrostriatal system; D1 and 5-HT
2A
receptors in the hypothalamus; and monoamine oxidase A (MAO A) in the frontal cortex). Decreased genetic control of the DA system may contribute to the spaceflight-induced locomotor impairment and dyskinesia described for both humans and rats.</description><subject>Animals</subject><subject>Behavior, Animal - physiology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Brain - metabolism</subject><subject>Cell Biology</subject><subject>Dopamine</subject><subject>Dopamine - metabolism</subject><subject>Gene expression</subject><subject>Gene Expression Regulation - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Mice, Inbred C57BL</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Receptor, Serotonin, 5-HT2A - metabolism</subject><subject>Rodents</subject><subject>Serotonin</subject><subject>Serotonin - metabolism</subject><subject>Space Flight</subject><subject>Spacecraft</subject><subject>Stress</subject><subject>Time</subject><subject>Weightlessness</subject><issn>0893-7648</issn><issn>1559-1182</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpNkMtOwzAQRS0EoqXwAWyQJdYGP-JH2EF5SlWRaFlbTjoJKU0c7GTRvydVi8Rm7mKO7mgOQpeM3jBK9W1knApJKEuIMZwRfYTGTMqUMGb4MRpTkwqiVWJG6CzGNaWcM6pP0YhLahIt9RjNP6r4jefQB19CAxEXPuCZb0qyhFDjRetyKDZV-dXd4UffurpqALtmhRcQfOebqsEPwQ1zsY0d1OfopHCbCBeHnKDP56fl9JXM3l_epvcz0jKddiRPeeKAghSFdEqBo1wqqvKMM5WDSETCVgCpplKq3GiTSUgzyZnJXVoUOhcTdL3vbYP_6SF2du370AwnLVOGiUGL5gN1daD6rIaVbUNVu7C1f-8PAN8DcVg1JYR_NdTuHNu9Yzs4tjvHVotfwMNrXg</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Popova, N. 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K. ; Kulikov, A. V. ; Kondaurova, E. M. ; Tsybko, A. S. ; Kulikova, E. A. ; Krasnov, I. B. ; Shenkman, B. S. ; Bazhenova, E. Yu ; Sinyakova, N. A. ; Naumenko, V. 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K.</au><au>Kulikov, A. V.</au><au>Kondaurova, E. M.</au><au>Tsybko, A. S.</au><au>Kulikova, E. A.</au><au>Krasnov, I. B.</au><au>Shenkman, B. S.</au><au>Bazhenova, E. Yu</au><au>Sinyakova, N. A.</au><au>Naumenko, V. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk Neurogenes for Long-Term Spaceflight: Dopamine and Serotonin Brain System</atitle><jtitle>Molecular neurobiology</jtitle><stitle>Mol Neurobiol</stitle><addtitle>Mol Neurobiol</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>51</volume><issue>3</issue><spage>1443</spage><epage>1451</epage><pages>1443-1451</pages><issn>0893-7648</issn><eissn>1559-1182</eissn><abstract>Mice were exposed to 1 month of spaceflight on Russian biosatellite BION-M1 to determine its effect on the expression of key genes in the brain dopamine (DA) and serotonin (5-HT) systems. Spaceflight decreased the expression of crucial genes involved in DA synthesis and degradation, as well as the D1 receptor. However, spaceflight failed to alter the expression of tryptophan hydroxylase-2, 5-HT transporter, 5-HT
1A
, and 5-HT
3
receptor genes, though it reduced 5-HT
2A
receptor gene expression in the hypothalamus. We revealed risk DA and 5-HT neurogenes for long-term spaceflight for the first time, as well as microgravity-responsive genes (tyrosine hydroxylase, catechol-O-methyltransferase, and D1 receptor in the nigrostriatal system; D1 and 5-HT
2A
receptors in the hypothalamus; and monoamine oxidase A (MAO A) in the frontal cortex). Decreased genetic control of the DA system may contribute to the spaceflight-induced locomotor impairment and dyskinesia described for both humans and rats.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>25084757</pmid><doi>10.1007/s12035-014-8821-7</doi><tpages>9</tpages></addata></record> |
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subjects | Animals Behavior, Animal - physiology Biomedical and Life Sciences Biomedicine Brain Brain - metabolism Cell Biology Dopamine Dopamine - metabolism Gene expression Gene Expression Regulation - physiology Humans Male Mice, Inbred C57BL Neurobiology Neurology Neurosciences Receptor, Serotonin, 5-HT2A - metabolism Rodents Serotonin Serotonin - metabolism Space Flight Spacecraft Stress Time Weightlessness |
title | Risk Neurogenes for Long-Term Spaceflight: Dopamine and Serotonin Brain System |
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