One-Pot Synthesis of 2-Amino-1,3-selenazole via an Intermediary Amidinoselenourea

Herein we describe a sequential one‐pot multicomponent reaction for the synthesis of 2‐amino‐1,3‐selenazole. Amidinoselenourea synthesized from isoselenocyanate and N,N‐diethyl‐amidine reacted with various halomethylene compounds to furnish 2‐amino‐1,3‐selenazole derivatives in 65–89 % yields. The molecular structure of the trisubstituted selenazole formed was unambiguously established by X‐ray crystallography. An efficient method for the synthesis of 2‐amino‐1,3‐selenazole by a sequential one‐pot multicomponent reaction between isoselenocyanate and N,N‐diethyl‐amidine has been developed. It represents a step‐economical way to construct a range of 2‐amino‐1,3‐selenazole derivatives in 65–89 % yields. The structure of the trisubstituted selenazole formed was unambiguously established by X‐ray crystallography.