EVALUACION DE LA ACTIVIDAD CITOTOXICA Y ANTIMICROBIANA DEL COMPUESTO [Ag(phen)2]salH

This article evaluated the antimicrobial and cytotoxic activity of a new complex of silver(I) with the salicylate ion and 1,10-phenanthroline. The characterization of this compounds was performed by nuclear magnetic resonance spectroscopy of proton and carbon-13 (RMN 1H y 13C), spectroscopy absorption in the infrared (IR), thermal analysis (TG/DCS) and elemental analysis (CHN). The results obtained through these methods suggest the formation of the compound with empirical formula Ag(phen)2]salH 4. When was compared the antimicrobial activity and cytotoxicity of the complex with other compounds of silver(I) and copper(II) of known activity, we observed that 1, 10-phenalthroline ligand increases these properties. The compound under study has the highest inhibition of bacterial growth, Gram-positive microorganisms were the most susceptible. The cytotoxic activity was tested against a panel of ve human cancer cell lines: MDA-MB231, PC-3, HT-29, HEp-2 and A549. At the concentrations tested, the compound produced a dose-dependent cytotoxic response against all tumor cell lines, particularly against the HT-29, MDA-MB231 and A549 cell lines. All this suggests its potential chemotherapeutic use.