ANALYSIS OF ENDOMYOCARDIAL BIOPSIES IN CARDIOMYOPATHIES: DIAGNOSTIC VALUE ON LEFT VERSUS RIGHT VENTRICULAR BIOPSY

ANALYSIS OF ENDOMYOCARDIAL BIOPSIES IN CARDIOMYOPATHIES: DIAGNOSTIC VALUE ON LEFT VERSUS RIGHT VENTRICULAR BIOPSY

Increased fibrosis was obtained by histological analysis in LV-EMBs of 18 (27.6%) patients, whereas only 3 (4.6%) patients with RV-EMB exhibited attenuated collagen deposition. [...]mRNA abundance of collagen I subtype, [alpha]-smooth muscle protein and hypertrophic phenotype of cardiac myocytes wer...

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Veröffentlicht in:Journal of the American College of Cardiology 2015-03, Vol.65 (10), p.A930-A930
Hauptverfasser: Escher, Felicitas, Kuhl, Uwe, Lassner, Dirk, Westermann, Dirk, Poller, Wolfgang, Tschoepe, Carsten, Schultheiss, Heinz-Peter
Format: Artikel
Sprache:eng
Schlagworte:
Biopsy
Cardiology
Cardiovascular
Cell adhesion & migration
Genomes
Internal Medicine
Morphology
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Zusammenfassung:Increased fibrosis was obtained by histological analysis in LV-EMBs of 18 (27.6%) patients, whereas only 3 (4.6%) patients with RV-EMB exhibited attenuated collagen deposition. [...]mRNA abundance of collagen I subtype, [alpha]-smooth muscle protein and hypertrophic phenotype of cardiac myocytes were significantly increased in LV- compared to RV-EMB (P=0.03), indicating better detection of matricellular remodeling.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(15)60930-5