TICAGRELOR POTENTIATES NEUTROPHIL PHAGOCYTOSIS VIA INHIBITION OF ADENOSINE REUPTAKE BY ERYTHROCYTES

TICAGRELOR POTENTIATES NEUTROPHIL PHAGOCYTOSIS VIA INHIBITION OF ADENOSINE REUPTAKE BY ERYTHROCYTES

Results: In the presence of erythrocytes, a low concentration of adenosine (10 nM) significantly increased neutrophil phagocytosis compared to control when ticagrelor was present (37.6±6.6 vs. 28.0±6.6; p=0.028) but had no effect in the absence of ticagrelor (25.3±5.6 vs. 25.1±7.5; p>0.05).

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Veröffentlicht in:Journal of the American College of Cardiology 2015-03, Vol.65 (10), p.A259-A259
Hauptverfasser: Thomas, Mark R, Alsharif, Khalaf F, Prince, Lynne R, Ridger, Victoria C, Judge, Heather M, Dockrell, David H, Sabroe, Ian, Storey, Robert F
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine
Cardiology
Cardiovascular
Fish
Internal Medicine
Streptococcus infections
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Zusammenfassung:Results: In the presence of erythrocytes, a low concentration of adenosine (10 nM) significantly increased neutrophil phagocytosis compared to control when ticagrelor was present (37.6±6.6 vs. 28.0±6.6; p=0.028) but had no effect in the absence of ticagrelor (25.3±5.6 vs. 25.1±7.5; p>0.05).
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(15)60259-5