COMPOUND 21, A SELECTIVE ANGIOTENSINII TYPE 2 RECEPTOR AGONIST, DOWNREGULATES LIPOPOLYSACCHARIDE-STIMULATED TISSUE FACTOR EXPRESSION IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS ACTIVATED BY EXPOSURE TO HIGH GLUCOSE

COMPOUND 21, A SELECTIVE ANGIOTENSINII TYPE 2 RECEPTOR AGONIST, DOWNREGULATES LIPOPOLYSACCHARIDE-STIMULATED TISSUE FACTOR EXPRESSION IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS ACTIVATED BY EXPOSURE TO HIGH GLUCOSE

Background: An intricate cross-talk connects Tissue Factor (TF) to inflammation and is amplified by locally active angiotensin(ang)II, a proinflammatory agent that stimulates TF expression through angII type1 receptors stimulation, a process potentiated by exposure of peripheral blood mononuclear ce...

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Veröffentlicht in:Journal of the American College of Cardiology 2015-03, Vol.65 (10), p.A254-A254
Hauptverfasser: Balia, Cristina, Scalise, Valentina, Petrini, Silvia, Neri, Tommaso, Cianchetti, Silvana, Celi, Alessandro, Pedrinelli, Roberto
Format: Artikel
Sprache:eng
Schlagworte:
Antigens
Cardiology
Cardiovascular
Internal Medicine
Medical research
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Zusammenfassung:Background: An intricate cross-talk connects Tissue Factor (TF) to inflammation and is amplified by locally active angiotensin(ang)II, a proinflammatory agent that stimulates TF expression through angII type1 receptors stimulation, a process potentiated by exposure of peripheral blood mononuclear cells (PBMCs) to high glucose.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(15)60254-6