A Concise and Scalable Strategy for the Total Synthesis of DictyodendrinB Based on Sequential CH Functionalization

A Concise and Scalable Strategy for the Total Synthesis of DictyodendrinB Based on Sequential CH Functionalization

A sequential CH functionalization strategy for the synthesis of the marine alkaloid dictyodendrinB is reported. Our synthesis begins from commercially available 4-bromoindole and involves six direct functionalizations around the heteroarene core as part of a gram-scale strategy towards the natural p...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie 2015-04, Vol.127 (18), p.5541
Hauptverfasser: Pitts, Andrew K, O'Hara, Fionn, Snell, Robert H, Gaunt, Matthew J
Format: Artikel
Sprache:ger
Schlagworte:
Chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A sequential CH functionalization strategy for the synthesis of the marine alkaloid dictyodendrinB is reported. Our synthesis begins from commercially available 4-bromoindole and involves six direct functionalizations around the heteroarene core as part of a gram-scale strategy towards the natural product.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201500067