QTC PROLONGATION CORRELATES WITH PLASMA ETHYLIDENE-1.5-DIMETHYL-3.3-DIPHENYLPYRROLIDENE (EDDP) AMONG SUBJECTS INITIATING METHADONE MAINTENANCE THERAPY

QTC PROLONGATION CORRELATES WITH PLASMA ETHYLIDENE-1.5-DIMETHYL-3.3-DIPHENYLPYRROLIDENE (EDDP) AMONG SUBJECTS INITIATING METHADONE MAINTENANCE THERAPY

Peak (4 hr post-oral dose) and trough (24 hr) plasma samples obtained on days 1, 7 and 21 were analyzed for methadone and EDDP (the principal methadone metabolite) by liquid chromatographic tandem mass spectrometry.

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Veröffentlicht in:Journal of the American College of Cardiology 2013-03, Vol.61 (10), p.E1336-E1336
Hauptverfasser: Carlquist, John, Moody, David, Johnson, Eric, Jacobsen, Marian, Huntinghouse, John, Rollo, Jeffrey, Knight, Stacey, Fang, Wenfang, Niemann, Dawn, Morgan, Mark, Muhlestein, J, Anderson, Jeffrey
Format: Artikel
Sprache:eng
Schlagworte:
Cardiac arrhythmia
Cardiology
Cardiovascular
Drug therapy
Internal Medicine
Methadone
Plasma
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Zusammenfassung:Peak (4 hr post-oral dose) and trough (24 hr) plasma samples obtained on days 1, 7 and 21 were analyzed for methadone and EDDP (the principal methadone metabolite) by liquid chromatographic tandem mass spectrometry.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(13)61336-4