TACC3 promotes epithelial–mesenchymal transition (EMT) through the activation of PI3K/Akt and ERK signaling pathways

Highlights ► TACC3 has an ability to regulate cell proliferation, migration, invasion and transformation. ► Overexpression of TACC3 promotes EMT, at least in part, through the up-regulation of PI3K/Akt and ERK signaling pathways. ► Depletion of TACC3 reverses EMT.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2013-05, Vol.332 (1), p.63-73
Hauptverfasser:	Ha, Geun-Hyoung, Park, Jong-Sup, Breuer, Eun-Kyoung Yim
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquisitions & mergers Akt beta Catenin - metabolism carcinogenesis Cell Movement Cell Proliferation Cell Shape Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Cervical cancer Chromosomes EMT Enzyme Activation Epidermal growth factor Epithelial-Mesenchymal Transition - drug effects ERKs Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - genetics Extracellular Signal-Regulated MAP Kinases - metabolism Fluorides Gene expression HEK293 Cells HeLa Cells Hematology, Oncology and Palliative Medicine Humans Kinases Metastasis Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism migratory behavior mitosis mitotic spindle apparatus Mutation Neoplasm Invasiveness Ovarian cancer phenotype phosphatidylinositol 3-kinase Phosphatidylinositol 3-Kinase - antagonists & inhibitors Phosphatidylinositol 3-Kinase - metabolism Phosphorylation PI3K Plasmids Protein Kinase Inhibitors - pharmacology protein kinases Proteins Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism RNA Interference signal transduction Signal Transduction - drug effects Sodium Studies TACC3 Time Factors Transfection
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Beschreibung
Zusammenfassung:	Highlights ► TACC3 has an ability to regulate cell proliferation, migration, invasion and transformation. ► Overexpression of TACC3 promotes EMT, at least in part, through the up-regulation of PI3K/Akt and ERK signaling pathways. ► Depletion of TACC3 reverses EMT.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2013.01.013