Monitoring of the Formation and Development Process for Infection and Inflammation Using F-18 FDG, PET/CT

The aim of the study, the process of formation and development of infection and inflammation is monitored using (18 F) 2'-deoxy-2-fluoro- D-glucose (F-18 FDG) by Positron Emission Computed Tomography (PET-CT). In this study, sterile abscess was induced by using turpentine and infected abscess was induced by using Staphylococcus aureus atcc 25923 strain on rats. In the abscess formation on rats, three groups rats were used as sterile, infected and control groups. There were examined male White Wistar Rats, the clinical healthy animals were 150-220 gr body weight. SUVmaxs were obtained from the images for evaluation glucose meatabolism of infection and inflammation detected by 18F-FDG, PET/CT. A soft tissue infection developed in the right arm site of the rats within 24 hours after bacterial inoculation. Swelling and redness of the abscess area was apparently seen in all rats. Abscess in rats were visualized by 18F-FDG, PET/CT. The higher abscess/ background rate was seen 1. hour than 2. hour after injection 18F-FDG.