OP-182 The Role of Serum Copeptin in Evaluation of Myocardial Perfusion Scintigraphy

Copeptin, the c-terminal part of the vasopressin prohormone, is released stochiometrically with arginin-vasopressin from the neurohypophysis and seems to reflect the individual endogenous stress level and also the mortality risk in coronary events. Normal Group (n=23) Equivocal Group (n=20) Ischemia Group (n=19) p value Age (year) 52±12 48±10 54±10 0.161 Gender (F/M) 17/6 (74/26) 12/8 (60/40) 11/8 (58/42) 0.489 Height (cm) 162±4 161±4 164±3 0.100 Weight (kg) 71±3 71±4 72±6 0.511 BMI (kg/m2) 27.1±1.7 27.5 ±1.6 27.0±2.2 0.445 DM n (%) 7 (30) 4 (20) 3 (16) 0.499 HT n (%) 8 (35) 2 (10) 6 (32) 0.142 Cigarette smoking n (%) 4 (17) 6 (30) 5 (26) 0.608 Family history of premature CAD n (%) 5 (22) 3 (15) 4 (21) 0.834 HL n (%) 1(4) 0 (0) 3 (15) 0.117 SBP (mmHg) 120±11 121±10 127±11 0.169 DBP (mmHg) 76±4 77±3 75±4 0.279 LVEF (%) 62±3 64±3 62±2 0.061 LA diameter (mm) 37±3 37±2 39±2 0.070 Mitral anulus lateral TDI Em/Am 1.48±0.78 1.66±0.60 1.34±0.66 0.364 Pre-exercise BNP (pg/ml) 10.0±1.8 9.4±1.6 10.3±3.1 0.467 Peak-exercise BNP (pg/ml) 14.5±5.5 11.3±1.9 12.5±3.8 0.078 Post-exercise BNP (pg/ml) 9.0±1.3 8.3±1.2 9.2±2.4 0.330 Pre-exercise Troponin I (ng/ml) 0.064±0.008 0.064±0.007 0.062±0.005 0.712 Peak-exercise Troponin I (ng/ml) 0.085±0.012 0.082±0.014 0.084±0.011 0.884 Post-exercise Troponin I (ng/ml) 0.070±0.016 0.066±0.009 0.074±0.016 0.296 Pre-exercise copeptin (pg/ml) 7.7±0.7 7.7±0.6 7.8±0.7 0.883 Peak-exercise copeptin (pg/ml) 9.2±1.5 9.5±1.8 10.5±1.8 0.089 Post-exercise copeptin (pg/ml) 7.7±2.7 7.8±2.5 12.2±2.0 0.000 Table The comparison of the groups in respect to clinical, echocardiographic and biochemical data.