A case of respiratory depression in a child with ultrarapid CYP2D6 metabolism after tramadol

A case of respiratory depression in a child with ultrarapid CYP2D6 metabolism after tramadol

We discuss a case of severe respiratory depression in a child, with ultrarapid CYP2D6 genotype and obstructive sleep apnea syndrome, after taking tramadol for pain relief related to a day-case tonsillectomy.

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Bibliographische Detailangaben
Veröffentlicht in:Pediatrics (Evanston) 2015-03, Vol.135 (3), p.e753-e755
Hauptverfasser: Orliaguet, Gilles, Hamza, Jamil, Couloigner, Vincent, Denoyelle, Françoise, Loriot, Marie-Anne, Broly, Franck, Garabedian, Erea Noel
Format: Artikel
Sprache:eng
Schlagworte:
Analgesics, Opioid - adverse effects
Analgesics, Opioid - therapeutic use
Care and treatment
Case studies
Child, Preschool
Childhood depression
Children & youth
Complications and side effects
Cytochrome P-450 CYP2D6 - drug effects
Cytochrome P-450 CYP2D6 - genetics
Cytochrome P-450 CYP2D6 - metabolism
Depression in children
Genotype
Genotype & phenotype
Humans
Hypoventilation
Male
Metabolism
Narcotics
Pain, Postoperative - drug therapy
Pediatrics
Respiratory diseases
Respiratory Insufficiency - enzymology
Respiratory Insufficiency - etiology
Risk factors
Sleep apnea
Tonsillectomy
Tramadol
Tramadol - adverse effects
Tramadol - therapeutic use
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Beschreibung
Zusammenfassung:We discuss a case of severe respiratory depression in a child, with ultrarapid CYP2D6 genotype and obstructive sleep apnea syndrome, after taking tramadol for pain relief related to a day-case tonsillectomy.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2014-2673