Improved Reference Measurement Method for Hemoglobin A^sub 1c^ by Use of Liquid Chromatography-Isotope Dilution-Tandem Mass Spectrometry

Improved Reference Measurement Method for Hemoglobin A^sub 1c^ by Use of Liquid Chromatography-Isotope Dilution-Tandem Mass Spectrometry

Valine was found to be unsuitable, possibly owing to its linkage to a deoxyfructoxyl group in GE. Because amino acid analysis is affected by both peptide and amino acid impurities, these impurities would need to be quantified (by HPLC and LC-MS/MS, respectively) to ensure the accuracy of the analysi...

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Veröffentlicht in:Clinical chemistry (Baltimore, Md.) Md.), 2015-02, Vol.61 (2), p.435
Hauptverfasser: Wong, Lingkai, Liu, Hong, Yong, Sharon, Liu, Qinde, Lee, Tong Kooi
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Calibration
Chromatography
Hemoglobin
Liquid chromatography
Mass spectrometry
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Zusammenfassung:Valine was found to be unsuitable, possibly owing to its linkage to a deoxyfructoxyl group in GE. Because amino acid analysis is affected by both peptide and amino acid impurities, these impurities would need to be quantified (by HPLC and LC-MS/MS, respectively) to ensure the accuracy of the analysis and subsequently the Hb A1c measurement.
ISSN:0009-9147
1530-8561