Cover Picture: Macromol. Biosci. 2/2014

Front Cover: Macromolecular prodrugs of ribavirin are synthesized by Alexander N. Zelikin and colleagues to overcome the origin of the main side effect of this drug, namely, accumulation in the red blood cells. On page 173, polymeric prodrugs are successful in accomplishing set goal, deliver their payload into the cells with hepatic relevance, and elicit a therapeutic response comparable to the parent drug. Together, these results constitute a major step forward towards safer delivery of ribavirin, a broad spectrum antiviral agent.