A 9-Valent HPV Vaccine against Infection and Intraepithelial Neoplasia in Women
The quadrivalent human papillomavirus vaccine is effective in preventing infection and disease related to HPV types 6, 11, 16, and 18. This phase 3 trial involving 14,000 women reports the efficacy of a 9-valent vaccine that targets additional HPV types. The human papillomavirus (HPV) causes premali...
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| Veröffentlicht in: | The New England journal of medicine 2015-02, Vol.372 (8), p.711-723 |
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| creator | Joura, Elmar A Giuliano, Anna R Iversen, Ole-Erik Bouchard, Celine Mao, Constance Mehlsen, Jesper Moreira, Edson D Ngan, Yuen Petersen, Lone Kjeld Lazcano-Ponce, Eduardo Pitisuttithum, Punnee Restrepo, Jaime Alberto Stuart, Gavin Woelber, Linn Yang, Yuh Cheng Cuzick, Jack Garland, Suzanne M Huh, Warner Kjaer, Susanne K Bautista, Oliver M Chan, Ivan S.F Chen, Joshua Gesser, Richard Moeller, Erin Ritter, Michael Vuocolo, Scott Luxembourg, Alain |
| description | The quadrivalent human papillomavirus vaccine is effective in preventing infection and disease related to HPV types 6, 11, 16, and 18. This phase 3 trial involving 14,000 women reports the efficacy of a 9-valent vaccine that targets additional HPV types.
The human papillomavirus (HPV) causes premalignant and malignant lesions of the cervix,
1
,
2
vagina,
3
,
4
vulva,
4
,
5
anus,
4
,
6
penis,
7
and oropharynx,
8
as well as genital warts.
9
,
10
The recent development of prophylactic vaccines directed against the most relevant disease-causing HPV types has helped to prevent diseases related to HPV.
11
In clinical trials, the bivalent HPV viruslike particle vaccine against HPV types 16 and 18 was efficacious against related infection with these types and against cervical dysplasia,
12
and the quadrivalent HPV viruslike particle vaccine against types 6, 11, 16, and 18 was efficacious against related infection and against cervical, vaginal, . . . |
| doi_str_mv | 10.1056/NEJMoa1405044 |
| format | Article |
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The human papillomavirus (HPV) causes premalignant and malignant lesions of the cervix,
1
,
2
vagina,
3
,
4
vulva,
4
,
5
anus,
4
,
6
penis,
7
and oropharynx,
8
as well as genital warts.
9
,
10
The recent development of prophylactic vaccines directed against the most relevant disease-causing HPV types has helped to prevent diseases related to HPV.
11
In clinical trials, the bivalent HPV viruslike particle vaccine against HPV types 16 and 18 was efficacious against related infection with these types and against cervical dysplasia,
12
and the quadrivalent HPV viruslike particle vaccine against types 6, 11, 16, and 18 was efficacious against related infection and against cervical, vaginal, . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1405044</identifier><identifier>PMID: 25693011</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Adolescent ; Adult ; Alphapapillomavirus ; Antibodies, Viral - blood ; Antibody response ; Biopsy ; Cervical cancer ; Deoxyribonucleic acid ; DNA ; Double-Blind Method ; Female ; Genital Diseases, Female - epidemiology ; Human papillomavirus ; Humans ; Immunization ; Immunogenicity ; Incidence ; Intention to Treat Analysis ; Motivation ; Papillomavirus Infections - epidemiology ; Papillomavirus Infections - prevention & control ; Papillomavirus Vaccines - administration & dosage ; Papillomavirus Vaccines - adverse effects ; Papillomavirus Vaccines - immunology ; Uterine Cervical Dysplasia - prevention & control ; Uterine Cervical Dysplasia - virology ; Uterine Cervical Neoplasms - prevention & control ; Uterine Cervical Neoplasms - virology ; Vaccines ; Vagina ; Women ; Young Adult</subject><ispartof>The New England journal of medicine, 2015-02, Vol.372 (8), p.711-723</ispartof><rights>Copyright © 2015 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1405044$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa1405044$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25693011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Joura, Elmar A</creatorcontrib><creatorcontrib>Giuliano, Anna R</creatorcontrib><creatorcontrib>Iversen, Ole-Erik</creatorcontrib><creatorcontrib>Bouchard, Celine</creatorcontrib><creatorcontrib>Mao, Constance</creatorcontrib><creatorcontrib>Mehlsen, Jesper</creatorcontrib><creatorcontrib>Moreira, Edson D</creatorcontrib><creatorcontrib>Ngan, Yuen</creatorcontrib><creatorcontrib>Petersen, Lone Kjeld</creatorcontrib><creatorcontrib>Lazcano-Ponce, Eduardo</creatorcontrib><creatorcontrib>Pitisuttithum, Punnee</creatorcontrib><creatorcontrib>Restrepo, Jaime Alberto</creatorcontrib><creatorcontrib>Stuart, Gavin</creatorcontrib><creatorcontrib>Woelber, Linn</creatorcontrib><creatorcontrib>Yang, Yuh Cheng</creatorcontrib><creatorcontrib>Cuzick, Jack</creatorcontrib><creatorcontrib>Garland, Suzanne M</creatorcontrib><creatorcontrib>Huh, Warner</creatorcontrib><creatorcontrib>Kjaer, Susanne K</creatorcontrib><creatorcontrib>Bautista, Oliver M</creatorcontrib><creatorcontrib>Chan, Ivan S.F</creatorcontrib><creatorcontrib>Chen, Joshua</creatorcontrib><creatorcontrib>Gesser, Richard</creatorcontrib><creatorcontrib>Moeller, Erin</creatorcontrib><creatorcontrib>Ritter, Michael</creatorcontrib><creatorcontrib>Vuocolo, Scott</creatorcontrib><creatorcontrib>Luxembourg, Alain</creatorcontrib><creatorcontrib>Broad Spectrum HPV Vaccine Study</creatorcontrib><title>A 9-Valent HPV Vaccine against Infection and Intraepithelial Neoplasia in Women</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>The quadrivalent human papillomavirus vaccine is effective in preventing infection and disease related to HPV types 6, 11, 16, and 18. This phase 3 trial involving 14,000 women reports the efficacy of a 9-valent vaccine that targets additional HPV types.
The human papillomavirus (HPV) causes premalignant and malignant lesions of the cervix,
1
,
2
vagina,
3
,
4
vulva,
4
,
5
anus,
4
,
6
penis,
7
and oropharynx,
8
as well as genital warts.
9
,
10
The recent development of prophylactic vaccines directed against the most relevant disease-causing HPV types has helped to prevent diseases related to HPV.
11
In clinical trials, the bivalent HPV viruslike particle vaccine against HPV types 16 and 18 was efficacious against related infection with these types and against cervical dysplasia,
12
and the quadrivalent HPV viruslike particle vaccine against types 6, 11, 16, and 18 was efficacious against related infection and against cervical, vaginal, . . .</description><subject>Adolescent</subject><subject>Adult</subject><subject>Alphapapillomavirus</subject><subject>Antibodies, Viral - blood</subject><subject>Antibody response</subject><subject>Biopsy</subject><subject>Cervical cancer</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Genital Diseases, Female - epidemiology</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunogenicity</subject><subject>Incidence</subject><subject>Intention to Treat Analysis</subject><subject>Motivation</subject><subject>Papillomavirus Infections - epidemiology</subject><subject>Papillomavirus Infections - prevention & control</subject><subject>Papillomavirus Vaccines - administration & dosage</subject><subject>Papillomavirus Vaccines - adverse effects</subject><subject>Papillomavirus Vaccines - immunology</subject><subject>Uterine Cervical Dysplasia - prevention & control</subject><subject>Uterine Cervical Dysplasia - virology</subject><subject>Uterine Cervical Neoplasms - prevention & control</subject><subject>Uterine Cervical Neoplasms - virology</subject><subject>Vaccines</subject><subject>Vagina</subject><subject>Women</subject><subject>Young 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Joura, Elmar A</au><au>Giuliano, Anna R</au><au>Iversen, Ole-Erik</au><au>Bouchard, Celine</au><au>Mao, Constance</au><au>Mehlsen, Jesper</au><au>Moreira, Edson D</au><au>Ngan, Yuen</au><au>Petersen, Lone Kjeld</au><au>Lazcano-Ponce, Eduardo</au><au>Pitisuttithum, Punnee</au><au>Restrepo, Jaime Alberto</au><au>Stuart, Gavin</au><au>Woelber, Linn</au><au>Yang, Yuh Cheng</au><au>Cuzick, Jack</au><au>Garland, Suzanne M</au><au>Huh, Warner</au><au>Kjaer, Susanne K</au><au>Bautista, Oliver M</au><au>Chan, Ivan S.F</au><au>Chen, Joshua</au><au>Gesser, Richard</au><au>Moeller, Erin</au><au>Ritter, Michael</au><au>Vuocolo, Scott</au><au>Luxembourg, Alain</au><aucorp>Broad Spectrum HPV Vaccine Study</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A 9-Valent HPV Vaccine against Infection and Intraepithelial Neoplasia in Women</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2015-02-19</date><risdate>2015</risdate><volume>372</volume><issue>8</issue><spage>711</spage><epage>723</epage><pages>711-723</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>The quadrivalent human papillomavirus vaccine is effective in preventing infection and disease related to HPV types 6, 11, 16, and 18. This phase 3 trial involving 14,000 women reports the efficacy of a 9-valent vaccine that targets additional HPV types.
The human papillomavirus (HPV) causes premalignant and malignant lesions of the cervix,
1
,
2
vagina,
3
,
4
vulva,
4
,
5
anus,
4
,
6
penis,
7
and oropharynx,
8
as well as genital warts.
9
,
10
The recent development of prophylactic vaccines directed against the most relevant disease-causing HPV types has helped to prevent diseases related to HPV.
11
In clinical trials, the bivalent HPV viruslike particle vaccine against HPV types 16 and 18 was efficacious against related infection with these types and against cervical dysplasia,
12
and the quadrivalent HPV viruslike particle vaccine against types 6, 11, 16, and 18 was efficacious against related infection and against cervical, vaginal, . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>25693011</pmid><doi>10.1056/NEJMoa1405044</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2015-02, Vol.372 (8), p.711-723 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_journals_1656387413 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Adolescent Adult Alphapapillomavirus Antibodies, Viral - blood Antibody response Biopsy Cervical cancer Deoxyribonucleic acid DNA Double-Blind Method Female Genital Diseases, Female - epidemiology Human papillomavirus Humans Immunization Immunogenicity Incidence Intention to Treat Analysis Motivation Papillomavirus Infections - epidemiology Papillomavirus Infections - prevention & control Papillomavirus Vaccines - administration & dosage Papillomavirus Vaccines - adverse effects Papillomavirus Vaccines - immunology Uterine Cervical Dysplasia - prevention & control Uterine Cervical Dysplasia - virology Uterine Cervical Neoplasms - prevention & control Uterine Cervical Neoplasms - virology Vaccines Vagina Women Young Adult |
| title | A 9-Valent HPV Vaccine against Infection and Intraepithelial Neoplasia in Women |
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