Astaxanthin from shrimp by-products ameliorates nephropathy in diabetic rats
AIM: This study investigated the hypoglycemic and antioxidant effects of shrimp astaxanthin on the kidney of alloxan-induced diabetic rats. METHODS: Animals were distributed into four groups of six rats each: a control group (C), a diabetic group (D), a diabetic group supplemented with Astaxanthin (...
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| Veröffentlicht in: | European journal of nutrition 2015-03, Vol.54 (2), p.301-307 |
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| creator | Sila, Assaâd Ghlissi, Zohra Kamoun, Zeineb Makni, Mohamed Nasri, Moncef Bougatef, Ali Sahnoun, Zouheir |
| description | AIM: This study investigated the hypoglycemic and antioxidant effects of shrimp astaxanthin on the kidney of alloxan-induced diabetic rats. METHODS: Animals were distributed into four groups of six rats each: a control group (C), a diabetic group (D), a diabetic group supplemented with Astaxanthin (D+As) dissolved in olive oil and a diabetic group supplemented with olive oil (D+OO). In vitro antidiabetic effect was tested in plasma and kidney tissue. RESULTS: The group D of rats showed significant (P |
| doi_str_mv | 10.1007/s00394-014-0711-2 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1653035534</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3586176551</sourcerecordid><originalsourceid>FETCH-LOGICAL-c532t-de375d1873f67106c480b83401d3851cd5415196ef0e6fa372291d7487c5915c3</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EolD4ADYQiXVgxo7jdFlVvKRKLKBry7GdJlXzwE4k-ve4SqlYsRjNSHPvHfsQcoPwgADi0QOwWRIDhhKIMT0hF5iwNE4p8tPjDGJCLr3fAABlKZ6TCU0yilTgBVnOfa--VdOXVRMVrq0jX7qq7qJ8F3euNYPufaRqu61ap3rro8Z2pWs71Ze7KFhMpXLbVzoKW39Fzgq19fb60Kdk9fz0uXiNl-8vb4v5Mtac0T42lgluMBOsSAVCqpMM8owlgIZlHLXhCXKcpbYAmxaKCUpnaESSCc1nyDWbkvsxN7zwa7C-l5t2cE04KTHlDBjnLAkqHFXatd47W8gu_Ey5nUSQe35y5CcDP7nnJ2nw3B6Sh7y25uj4BRYEdBT4sGrW1v05_U_q3WgqVCvV2lVerj4oIIdQiJSxHzbNgp0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1653035534</pqid></control><display><type>article</type><title>Astaxanthin from shrimp by-products ameliorates nephropathy in diabetic rats</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Sila, Assaâd ; Ghlissi, Zohra ; Kamoun, Zeineb ; Makni, Mohamed ; Nasri, Moncef ; Bougatef, Ali ; Sahnoun, Zouheir</creator><creatorcontrib>Sila, Assaâd ; Ghlissi, Zohra ; Kamoun, Zeineb ; Makni, Mohamed ; Nasri, Moncef ; Bougatef, Ali ; Sahnoun, Zouheir</creatorcontrib><description>AIM: This study investigated the hypoglycemic and antioxidant effects of shrimp astaxanthin on the kidney of alloxan-induced diabetic rats. METHODS: Animals were distributed into four groups of six rats each: a control group (C), a diabetic group (D), a diabetic group supplemented with Astaxanthin (D+As) dissolved in olive oil and a diabetic group supplemented with olive oil (D+OO). In vitro antidiabetic effect was tested in plasma and kidney tissue. RESULTS: The group D of rats showed significant (P < 0.05) increase of glycemia, creatinine, urea and uric acid levels compared to those of the control group (C). Moreover, plasma and kidney malondialdehyde (MDA) and protein carbonyl (PCO) levels for the rats of the group D were significantly increased compared to the control group. Contrariwise, antioxidant enzyme activities, such as catalase (EC 1.11.1.6), superoxide dismutase (EC 1.15.1.1) and non-enzymatic levels of reduced glutathione, were significantly (P < 0.05) decreased in the plasma and kidney of diabetic rats compared to the control ones. The astaxanthin supplementation in rats diet improved the antioxidant enzyme activities and significantly decreased the MDA and PCO levels compared to diabetic rats. Indeed, no significant (P ≥ 0.05) improvement was observed for the fourth group (D+OO) compared to the control group (C). Histological analysis of kidney showed glomerular hypertrophy and tubular dilatation for the diabetic rats. For D+As rats, these histopathological changes were less prominent. CONCLUSIONS: Our results suggest that shrimp astaxanthin may play an important role in reduction of oxidative damage and could prevent pathological changes in diabetic rats suggesting promising application of shrimp astaxanthin in diabet treatment.</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-014-0711-2</identifier><identifier>PMID: 24821271</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Animal Shells - chemistry ; Animals ; antioxidant activity ; antioxidants ; Antioxidants - adverse effects ; Antioxidants - economics ; Antioxidants - metabolism ; Antioxidants - therapeutic use ; astaxanthin ; blood glucose ; byproducts ; catalase ; Chemistry ; Chemistry and Materials Science ; creatinine ; Decapoda (Crustacea) - chemistry ; Diabetes Mellitus, Experimental - complications ; Diabetes Mellitus, Experimental - diet therapy ; Diabetes Mellitus, Experimental - metabolism ; Diabetes Mellitus, Experimental - pathology ; Diabetic Nephropathies - physiopathology ; Diabetic Nephropathies - prevention & control ; diabetic nephropathy ; diet ; Dietary Supplements - adverse effects ; Dietary Supplements - economics ; enzyme activity ; Food-Processing Industry - education ; glutathione ; Glutathione - antagonists & inhibitors ; Glutathione - blood ; Glutathione - metabolism ; glycemic effect ; histopathology ; Hyperglycemia - prevention & control ; hypertrophy ; Hypoglycemic Agents - adverse effects ; Hypoglycemic Agents - economics ; Hypoglycemic Agents - metabolism ; Hypoglycemic Agents - therapeutic use ; Kidney - drug effects ; Kidney - metabolism ; Kidney - pathology ; Kidney - physiopathology ; kidneys ; Lipid Peroxidation ; Male ; malondialdehyde ; Nutrition ; olive oil ; Original Contribution ; Oxidative Stress ; Oxidoreductases - antagonists & inhibitors ; Oxidoreductases - blood ; Oxidoreductases - metabolism ; rats ; Rats, Wistar ; Renal Insufficiency - complications ; Renal Insufficiency - physiopathology ; Renal Insufficiency - prevention & control ; shrimp ; superoxide dismutase ; urea ; uric acid ; Waste Products - analysis ; Waste Products - economics ; Xanthophylls - adverse effects ; Xanthophylls - economics ; Xanthophylls - metabolism ; Xanthophylls - therapeutic use</subject><ispartof>European journal of nutrition, 2015-03, Vol.54 (2), p.301-307</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-de375d1873f67106c480b83401d3851cd5415196ef0e6fa372291d7487c5915c3</citedby><cites>FETCH-LOGICAL-c532t-de375d1873f67106c480b83401d3851cd5415196ef0e6fa372291d7487c5915c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00394-014-0711-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00394-014-0711-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27933,27934,41497,42566,51328</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24821271$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sila, Assaâd</creatorcontrib><creatorcontrib>Ghlissi, Zohra</creatorcontrib><creatorcontrib>Kamoun, Zeineb</creatorcontrib><creatorcontrib>Makni, Mohamed</creatorcontrib><creatorcontrib>Nasri, Moncef</creatorcontrib><creatorcontrib>Bougatef, Ali</creatorcontrib><creatorcontrib>Sahnoun, Zouheir</creatorcontrib><title>Astaxanthin from shrimp by-products ameliorates nephropathy in diabetic rats</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>AIM: This study investigated the hypoglycemic and antioxidant effects of shrimp astaxanthin on the kidney of alloxan-induced diabetic rats. METHODS: Animals were distributed into four groups of six rats each: a control group (C), a diabetic group (D), a diabetic group supplemented with Astaxanthin (D+As) dissolved in olive oil and a diabetic group supplemented with olive oil (D+OO). In vitro antidiabetic effect was tested in plasma and kidney tissue. RESULTS: The group D of rats showed significant (P < 0.05) increase of glycemia, creatinine, urea and uric acid levels compared to those of the control group (C). Moreover, plasma and kidney malondialdehyde (MDA) and protein carbonyl (PCO) levels for the rats of the group D were significantly increased compared to the control group. Contrariwise, antioxidant enzyme activities, such as catalase (EC 1.11.1.6), superoxide dismutase (EC 1.15.1.1) and non-enzymatic levels of reduced glutathione, were significantly (P < 0.05) decreased in the plasma and kidney of diabetic rats compared to the control ones. The astaxanthin supplementation in rats diet improved the antioxidant enzyme activities and significantly decreased the MDA and PCO levels compared to diabetic rats. Indeed, no significant (P ≥ 0.05) improvement was observed for the fourth group (D+OO) compared to the control group (C). Histological analysis of kidney showed glomerular hypertrophy and tubular dilatation for the diabetic rats. For D+As rats, these histopathological changes were less prominent. CONCLUSIONS: Our results suggest that shrimp astaxanthin may play an important role in reduction of oxidative damage and could prevent pathological changes in diabetic rats suggesting promising application of shrimp astaxanthin in diabet treatment.</description><subject>Animal Shells - chemistry</subject><subject>Animals</subject><subject>antioxidant activity</subject><subject>antioxidants</subject><subject>Antioxidants - adverse effects</subject><subject>Antioxidants - economics</subject><subject>Antioxidants - metabolism</subject><subject>Antioxidants - therapeutic use</subject><subject>astaxanthin</subject><subject>blood glucose</subject><subject>byproducts</subject><subject>catalase</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>creatinine</subject><subject>Decapoda (Crustacea) - chemistry</subject><subject>Diabetes Mellitus, Experimental - complications</subject><subject>Diabetes Mellitus, Experimental - diet therapy</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetes Mellitus, Experimental - pathology</subject><subject>Diabetic Nephropathies - physiopathology</subject><subject>Diabetic Nephropathies - prevention & control</subject><subject>diabetic nephropathy</subject><subject>diet</subject><subject>Dietary Supplements - adverse effects</subject><subject>Dietary Supplements - economics</subject><subject>enzyme activity</subject><subject>Food-Processing Industry - education</subject><subject>glutathione</subject><subject>Glutathione - antagonists & inhibitors</subject><subject>Glutathione - blood</subject><subject>Glutathione - metabolism</subject><subject>glycemic effect</subject><subject>histopathology</subject><subject>Hyperglycemia - prevention & control</subject><subject>hypertrophy</subject><subject>Hypoglycemic Agents - adverse effects</subject><subject>Hypoglycemic Agents - economics</subject><subject>Hypoglycemic Agents - metabolism</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Kidney - physiopathology</subject><subject>kidneys</subject><subject>Lipid Peroxidation</subject><subject>Male</subject><subject>malondialdehyde</subject><subject>Nutrition</subject><subject>olive oil</subject><subject>Original Contribution</subject><subject>Oxidative Stress</subject><subject>Oxidoreductases - antagonists & inhibitors</subject><subject>Oxidoreductases - blood</subject><subject>Oxidoreductases - metabolism</subject><subject>rats</subject><subject>Rats, Wistar</subject><subject>Renal Insufficiency - complications</subject><subject>Renal Insufficiency - physiopathology</subject><subject>Renal Insufficiency - prevention & control</subject><subject>shrimp</subject><subject>superoxide dismutase</subject><subject>urea</subject><subject>uric acid</subject><subject>Waste Products - analysis</subject><subject>Waste Products - economics</subject><subject>Xanthophylls - adverse effects</subject><subject>Xanthophylls - economics</subject><subject>Xanthophylls - metabolism</subject><subject>Xanthophylls - therapeutic use</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kMtOwzAQRS0EolD4ADYQiXVgxo7jdFlVvKRKLKBry7GdJlXzwE4k-ve4SqlYsRjNSHPvHfsQcoPwgADi0QOwWRIDhhKIMT0hF5iwNE4p8tPjDGJCLr3fAABlKZ6TCU0yilTgBVnOfa--VdOXVRMVrq0jX7qq7qJ8F3euNYPufaRqu61ap3rro8Z2pWs71Ze7KFhMpXLbVzoKW39Fzgq19fb60Kdk9fz0uXiNl-8vb4v5Mtac0T42lgluMBOsSAVCqpMM8owlgIZlHLXhCXKcpbYAmxaKCUpnaESSCc1nyDWbkvsxN7zwa7C-l5t2cE04KTHlDBjnLAkqHFXatd47W8gu_Ey5nUSQe35y5CcDP7nnJ2nw3B6Sh7y25uj4BRYEdBT4sGrW1v05_U_q3WgqVCvV2lVerj4oIIdQiJSxHzbNgp0</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Sila, Assaâd</creator><creator>Ghlissi, Zohra</creator><creator>Kamoun, Zeineb</creator><creator>Makni, Mohamed</creator><creator>Nasri, Moncef</creator><creator>Bougatef, Ali</creator><creator>Sahnoun, Zouheir</creator><general>Springer-Verlag</general><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>20150301</creationdate><title>Astaxanthin from shrimp by-products ameliorates nephropathy in diabetic rats</title><author>Sila, Assaâd ; Ghlissi, Zohra ; Kamoun, Zeineb ; Makni, Mohamed ; Nasri, Moncef ; Bougatef, Ali ; Sahnoun, Zouheir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-de375d1873f67106c480b83401d3851cd5415196ef0e6fa372291d7487c5915c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animal Shells - chemistry</topic><topic>Animals</topic><topic>antioxidant activity</topic><topic>antioxidants</topic><topic>Antioxidants - adverse effects</topic><topic>Antioxidants - economics</topic><topic>Antioxidants - metabolism</topic><topic>Antioxidants - therapeutic use</topic><topic>astaxanthin</topic><topic>blood glucose</topic><topic>byproducts</topic><topic>catalase</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>creatinine</topic><topic>Decapoda (Crustacea) - chemistry</topic><topic>Diabetes Mellitus, Experimental - complications</topic><topic>Diabetes Mellitus, Experimental - diet therapy</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diabetes Mellitus, Experimental - pathology</topic><topic>Diabetic Nephropathies - physiopathology</topic><topic>Diabetic Nephropathies - prevention & control</topic><topic>diabetic nephropathy</topic><topic>diet</topic><topic>Dietary Supplements - adverse effects</topic><topic>Dietary Supplements - economics</topic><topic>enzyme activity</topic><topic>Food-Processing Industry - education</topic><topic>glutathione</topic><topic>Glutathione - antagonists & inhibitors</topic><topic>Glutathione - blood</topic><topic>Glutathione - metabolism</topic><topic>glycemic effect</topic><topic>histopathology</topic><topic>Hyperglycemia - prevention & control</topic><topic>hypertrophy</topic><topic>Hypoglycemic Agents - adverse effects</topic><topic>Hypoglycemic Agents - economics</topic><topic>Hypoglycemic Agents - metabolism</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidney - pathology</topic><topic>Kidney - physiopathology</topic><topic>kidneys</topic><topic>Lipid Peroxidation</topic><topic>Male</topic><topic>malondialdehyde</topic><topic>Nutrition</topic><topic>olive oil</topic><topic>Original Contribution</topic><topic>Oxidative Stress</topic><topic>Oxidoreductases - antagonists & inhibitors</topic><topic>Oxidoreductases - blood</topic><topic>Oxidoreductases - metabolism</topic><topic>rats</topic><topic>Rats, Wistar</topic><topic>Renal Insufficiency - complications</topic><topic>Renal Insufficiency - physiopathology</topic><topic>Renal Insufficiency - prevention & control</topic><topic>shrimp</topic><topic>superoxide dismutase</topic><topic>urea</topic><topic>uric acid</topic><topic>Waste Products - analysis</topic><topic>Waste Products - economics</topic><topic>Xanthophylls - adverse effects</topic><topic>Xanthophylls - economics</topic><topic>Xanthophylls - metabolism</topic><topic>Xanthophylls - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sila, Assaâd</creatorcontrib><creatorcontrib>Ghlissi, Zohra</creatorcontrib><creatorcontrib>Kamoun, Zeineb</creatorcontrib><creatorcontrib>Makni, Mohamed</creatorcontrib><creatorcontrib>Nasri, Moncef</creatorcontrib><creatorcontrib>Bougatef, Ali</creatorcontrib><creatorcontrib>Sahnoun, Zouheir</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>European journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sila, Assaâd</au><au>Ghlissi, Zohra</au><au>Kamoun, Zeineb</au><au>Makni, Mohamed</au><au>Nasri, Moncef</au><au>Bougatef, Ali</au><au>Sahnoun, Zouheir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Astaxanthin from shrimp by-products ameliorates nephropathy in diabetic rats</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>54</volume><issue>2</issue><spage>301</spage><epage>307</epage><pages>301-307</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>AIM: This study investigated the hypoglycemic and antioxidant effects of shrimp astaxanthin on the kidney of alloxan-induced diabetic rats. METHODS: Animals were distributed into four groups of six rats each: a control group (C), a diabetic group (D), a diabetic group supplemented with Astaxanthin (D+As) dissolved in olive oil and a diabetic group supplemented with olive oil (D+OO). In vitro antidiabetic effect was tested in plasma and kidney tissue. RESULTS: The group D of rats showed significant (P < 0.05) increase of glycemia, creatinine, urea and uric acid levels compared to those of the control group (C). Moreover, plasma and kidney malondialdehyde (MDA) and protein carbonyl (PCO) levels for the rats of the group D were significantly increased compared to the control group. Contrariwise, antioxidant enzyme activities, such as catalase (EC 1.11.1.6), superoxide dismutase (EC 1.15.1.1) and non-enzymatic levels of reduced glutathione, were significantly (P < 0.05) decreased in the plasma and kidney of diabetic rats compared to the control ones. The astaxanthin supplementation in rats diet improved the antioxidant enzyme activities and significantly decreased the MDA and PCO levels compared to diabetic rats. Indeed, no significant (P ≥ 0.05) improvement was observed for the fourth group (D+OO) compared to the control group (C). Histological analysis of kidney showed glomerular hypertrophy and tubular dilatation for the diabetic rats. For D+As rats, these histopathological changes were less prominent. CONCLUSIONS: Our results suggest that shrimp astaxanthin may play an important role in reduction of oxidative damage and could prevent pathological changes in diabetic rats suggesting promising application of shrimp astaxanthin in diabet treatment.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>24821271</pmid><doi>10.1007/s00394-014-0711-2</doi><tpages>7</tpages></addata></record> |
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| subjects | Animal Shells - chemistry Animals antioxidant activity antioxidants Antioxidants - adverse effects Antioxidants - economics Antioxidants - metabolism Antioxidants - therapeutic use astaxanthin blood glucose byproducts catalase Chemistry Chemistry and Materials Science creatinine Decapoda (Crustacea) - chemistry Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - diet therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetic Nephropathies - physiopathology Diabetic Nephropathies - prevention & control diabetic nephropathy diet Dietary Supplements - adverse effects Dietary Supplements - economics enzyme activity Food-Processing Industry - education glutathione Glutathione - antagonists & inhibitors Glutathione - blood Glutathione - metabolism glycemic effect histopathology Hyperglycemia - prevention & control hypertrophy Hypoglycemic Agents - adverse effects Hypoglycemic Agents - economics Hypoglycemic Agents - metabolism Hypoglycemic Agents - therapeutic use Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney - physiopathology kidneys Lipid Peroxidation Male malondialdehyde Nutrition olive oil Original Contribution Oxidative Stress Oxidoreductases - antagonists & inhibitors Oxidoreductases - blood Oxidoreductases - metabolism rats Rats, Wistar Renal Insufficiency - complications Renal Insufficiency - physiopathology Renal Insufficiency - prevention & control shrimp superoxide dismutase urea uric acid Waste Products - analysis Waste Products - economics Xanthophylls - adverse effects Xanthophylls - economics Xanthophylls - metabolism Xanthophylls - therapeutic use |
| title | Astaxanthin from shrimp by-products ameliorates nephropathy in diabetic rats |
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