Astaxanthin from shrimp by-products ameliorates nephropathy in diabetic rats

AIM: This study investigated the hypoglycemic and antioxidant effects of shrimp astaxanthin on the kidney of alloxan-induced diabetic rats. METHODS: Animals were distributed into four groups of six rats each: a control group (C), a diabetic group (D), a diabetic group supplemented with Astaxanthin (...

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Veröffentlicht in:	European journal of nutrition 2015-03, Vol.54 (2), p.301-307
Hauptverfasser:	Sila, Assaâd, Ghlissi, Zohra, Kamoun, Zeineb, Makni, Mohamed, Nasri, Moncef, Bougatef, Ali, Sahnoun, Zouheir
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Shells - chemistry Animals antioxidant activity antioxidants Antioxidants - adverse effects Antioxidants - economics Antioxidants - metabolism Antioxidants - therapeutic use astaxanthin blood glucose byproducts catalase Chemistry Chemistry and Materials Science creatinine Decapoda (Crustacea) - chemistry Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - diet therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetic Nephropathies - physiopathology Diabetic Nephropathies - prevention & control diabetic nephropathy diet Dietary Supplements - adverse effects Dietary Supplements - economics enzyme activity Food-Processing Industry - education glutathione Glutathione - antagonists & inhibitors Glutathione - blood Glutathione - metabolism glycemic effect histopathology Hyperglycemia - prevention & control hypertrophy Hypoglycemic Agents - adverse effects Hypoglycemic Agents - economics Hypoglycemic Agents - metabolism Hypoglycemic Agents - therapeutic use Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney - physiopathology kidneys Lipid Peroxidation Male malondialdehyde Nutrition olive oil Original Contribution Oxidative Stress Oxidoreductases - antagonists & inhibitors Oxidoreductases - blood Oxidoreductases - metabolism rats Rats, Wistar Renal Insufficiency - complications Renal Insufficiency - physiopathology Renal Insufficiency - prevention & control shrimp superoxide dismutase urea uric acid Waste Products - analysis Waste Products - economics Xanthophylls - adverse effects Xanthophylls - economics Xanthophylls - metabolism Xanthophylls - therapeutic use
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Zusammenfassung:	AIM: This study investigated the hypoglycemic and antioxidant effects of shrimp astaxanthin on the kidney of alloxan-induced diabetic rats. METHODS: Animals were distributed into four groups of six rats each: a control group (C), a diabetic group (D), a diabetic group supplemented with Astaxanthin (D+As) dissolved in olive oil and a diabetic group supplemented with olive oil (D+OO). In vitro antidiabetic effect was tested in plasma and kidney tissue. RESULTS: The group D of rats showed significant (P
ISSN:	1436-6207 1436-6215
DOI:	10.1007/s00394-014-0711-2