(1) Immunopharmacological Characterization of Potent, Selective and Orally Available ROR[gamma]t Inhibitors for Treatment of Autoimmune Diseases

(1) Immunopharmacological Characterization of Potent, Selective and Orally Available ROR[gamma]t Inhibitors for Treatment of Autoimmune Diseases

Specificity and safety profiles were assessed by BioMAP T cell autoimmune panel that models immunosuppression, anti-inflammatory action, tissue remodeling, Th1/Th2/Th17 skewing, and cell cytotoxicity in human primary cells.

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Veröffentlicht in:Journal of allergy and clinical immunology 2015-02, Vol.135 (2), p.AB98
Hauptverfasser: Masuda, Junya, Takeuchi, Takashi, Tomizawa, Chinatsu, Kawaji, Atsuko, Asakura, Toshimichi, Shimada, Shunsuke, Negishi, Takaaki, Kato, Yutaka, Nakao, Kazunari, Furusako, Shoji
Format: Artikel
Sprache:eng
Schlagworte:
Autoimmune diseases
Immune system
Rodents
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Zusammenfassung:Specificity and safety profiles were assessed by BioMAP T cell autoimmune panel that models immunosuppression, anti-inflammatory action, tissue remodeling, Th1/Th2/Th17 skewing, and cell cytotoxicity in human primary cells.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2014.12.1255