EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21waf1/cip1and by inhibiting mutant p53
The enhancer of zeste homolog 2 (EZH2) methyltransferase is a transcriptional repressor. EZH2 is abnormally elevated in epithelial ovarian cancer (EOC). We demonstrated that EZH2 knockdown inhibited cell growth, activated apoptosis, and enhanced chemosensitivity. Further, silencing of EZH2 resulted...
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| Veröffentlicht in: | Cancer letters 2013-08, Vol.336 (1), p.53 |
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| container_issue | 1 |
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| container_title | Cancer letters |
| container_volume | 336 |
| creator | Seward, Shelly Semaan, Assaad Qazi, Aamer M Gruzdyn, Oksana V Chamala, Sreedhar Bryant, Christopher C Kumar, Sanjeev Cameron, David Sethi, Seema Ali-Fehmi, Rouba Morris, Robert Bouwman, David L Munkarah, Adnan R Weaver, Donald W Gruber, Scott A Batchu, Ramesh B |
| description | The enhancer of zeste homolog 2 (EZH2) methyltransferase is a transcriptional repressor. EZH2 is abnormally elevated in epithelial ovarian cancer (EOC). We demonstrated that EZH2 knockdown inhibited cell growth, activated apoptosis, and enhanced chemosensitivity. Further, silencing of EZH2 resulted in re-expression of p21waf1/cip1and down-regulation of mutant p53. Finally, EZH2 knockdown contributed to attenuated EOC growth in SCID mice. |
| doi_str_mv | 10.1016/j.canlet.2013.04.012 |
| format | Article |
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| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2013-08, Vol.336 (1), p.53 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Amino acids Apoptosis Cancer therapies Cell growth Chemotherapy Cyclin-dependent kinases Gastric cancer Kinases Metastasis Ovarian cancer Studies Tumors |
| title | EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21waf1/cip1and by inhibiting mutant p53 |
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