EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21waf1/cip1and by inhibiting mutant p53

EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21waf1/cip1and by inhibiting mutant p53

The enhancer of zeste homolog 2 (EZH2) methyltransferase is a transcriptional repressor. EZH2 is abnormally elevated in epithelial ovarian cancer (EOC). We demonstrated that EZH2 knockdown inhibited cell growth, activated apoptosis, and enhanced chemosensitivity. Further, silencing of EZH2 resulted...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cancer letters 2013-08, Vol.336 (1), p.53
Hauptverfasser: Seward, Shelly, Semaan, Assaad, Qazi, Aamer M, Gruzdyn, Oksana V, Chamala, Sreedhar, Bryant, Christopher C, Kumar, Sanjeev, Cameron, David, Sethi, Seema, Ali-Fehmi, Rouba, Morris, Robert, Bouwman, David L, Munkarah, Adnan R, Weaver, Donald W, Gruber, Scott A, Batchu, Ramesh B
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Apoptosis
Cancer therapies
Cell growth
Chemotherapy
Cyclin-dependent kinases
Gastric cancer
Kinases
Metastasis
Ovarian cancer
Studies
Tumors
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The enhancer of zeste homolog 2 (EZH2) methyltransferase is a transcriptional repressor. EZH2 is abnormally elevated in epithelial ovarian cancer (EOC). We demonstrated that EZH2 knockdown inhibited cell growth, activated apoptosis, and enhanced chemosensitivity. Further, silencing of EZH2 resulted in re-expression of p21waf1/cip1and down-regulation of mutant p53. Finally, EZH2 knockdown contributed to attenuated EOC growth in SCID mice.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.04.012