Local bystander effect induces dormancy in human medullary thyroid carcinoma modelin vivo

Local bystander effect induces dormancy in human medullary thyroid carcinoma modelin vivo

Highlights * Fusion yeast cytosine deaminase/5-fluorocytosine is efficient GDEPT combination for MTC treatment. * yCD/5FC induces strong local bystander effect in MTC modelin vivo. * yCD/5FC treatment decreases serum calcitonin by 92.9% and arrests tumor cell proliferation.

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Veröffentlicht in:Cancer letters 2013-07, Vol.335 (2), p.299
Hauptverfasser: Kucerova, Lucia, Feketeova, Lucia, Matuskova, Miroslava, Kozovska, Zuzana, Janega, Pavol, Babal, Pavel, Poturnajova, Martina
Format: Artikel
Sprache:eng
Schlagworte:
Cell growth
Cytotoxicity
Efficiency
Enzymes
Kinases
Laboratories
Metabolites
R&D
Research & development
Rodents
Thyroid cancer
Yeast
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Zusammenfassung:Highlights * Fusion yeast cytosine deaminase/5-fluorocytosine is efficient GDEPT combination for MTC treatment. * yCD/5FC induces strong local bystander effect in MTC modelin vivo. * yCD/5FC treatment decreases serum calcitonin by 92.9% and arrests tumor cell proliferation.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.02.040