Cytosine deaminase-expressing human neural stem cells inhibit tumor growth in prostate cancer-bearing mice

Highlights ► No effective chemotherapy has yet been developed for advanced prostate cancer. ► Stem cells have selective migration ability toward cancer and therapeutic genes can be readily transduced into stem cells. ► Human neural stem cells were labeled with nanoparticles and systematically transp...

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Veröffentlicht in:	Cancer letters 2013-07, Vol.335 (1), p.58-65
Hauptverfasser:	Lee, Hong Jun, Doo, Seung Whan, Kim, Dae Hong, Cha, Young Joo, Kim, Jae Heon, Song, Yun Seob, Kim, Seung U
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites, Antineoplastic - pharmacokinetics Antimetabolites, Antineoplastic - therapeutic use Cell Line, Tumor Cell Movement Cell Survival - drug effects Cell Tracking Cells, Cultured chemotherapy cytosine Cytosine deaminase Cytosine Deaminase - biosynthesis cytotoxicity drugs Flucytosine - pharmacokinetics Flucytosine - therapeutic use gene therapy Genes Hematology, Oncology and Palliative Medicine Humans magnetic resonance imaging Male men Mice Mice, Inbred C57BL nanoparticles Neural Stem Cells - enzymology Neural Stem Cells - physiology Neural Stem Cells - transplantation Prodrugs - pharmacokinetics Prodrugs - therapeutic use Prostate cancer prostatic neoplasms Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Stem cell Stem cells Suicide gene Transplants & implants Tumor Burden - drug effects Tumor-tropism Xenograft Model Antitumor Assays
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Zusammenfassung:	Highlights ► No effective chemotherapy has yet been developed for advanced prostate cancer. ► Stem cells have selective migration ability toward cancer and therapeutic genes can be readily transduced into stem cells. ► Human neural stem cells were labeled with nanoparticles and systematically transplanted in mice bearing prostate cancer. ► Transplanted stem cells encoding cytosine deaminase migrated selectively toward the tumor. ► In combination with prodrug 5-fluorocytosine, the tumor burden was significantly reduced.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2013.01.048