Inhibition of TGF-[beta] signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages

Inhibition of TGF-[beta] signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages

Highlights * TLR7 expressed on TAMs but not the tumor cells. * Ligation of TLR7+ TGF-β receptor I inhibitor in TAM/tumor cell co-culture system re-programmed TAMs to M1 macrophage. * In vivo TLR7 ligation/TGF-β receptor I inhibition increased tumor apoptosis and elevated lymphocytes infiltration.

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Bibliographische Detailangaben
Veröffentlicht in:Cancer letters 2013-05, Vol.331 (2), p.239
Hauptverfasser: Peng, Jiao, Tsang, Julia Yuen Shan, Li, Daxu, Niu, Na, HO, Derek Hoi Hang, Lau, Kwok Fai, Lui, Vincent Chi Hang, Lamb, Jonathan Robert, Chen, Yan, Tam, Paul Kwong Hang
Format: Artikel
Sprache:eng
Schlagworte:
Angiogenesis
Genotype & phenotype
Kinases
Ligands
Medical prognosis
Metastasis
Studies
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Zusammenfassung:Highlights * TLR7 expressed on TAMs but not the tumor cells. * Ligation of TLR7+ TGF-β receptor I inhibitor in TAM/tumor cell co-culture system re-programmed TAMs to M1 macrophage. * In vivo TLR7 ligation/TGF-β receptor I inhibition increased tumor apoptosis and elevated lymphocytes infiltration.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.01.001