Identification and characterisation ofSTMN4andROBO2gene involvement in neuroblastoma cell differentiation

Identification and characterisation ofSTMN4andROBO2gene involvement in neuroblastoma cell differentiation

Highlights * STMN4andROBO2gene expression is consistently up-regulated in neuroblastoma cells induced to differentiate. * Ectopic expression of transfectedSTMN4orROBO2induces IMR-32 cells to differentiate, showing a causal link with the differentiated phenotype. * High tumourSTMN4andROBO2mRNA expres...

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Veröffentlicht in:Cancer letters 2013-01, Vol.328 (1), p.168
Hauptverfasser: Sung, Pei-Ju, Boulos, Nidal, Tilby, Michael John, Andrews, William David, Newbold, Robert Frank, Tweddle, Deborah Anne, Lunec, John
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Cancer
Chromosomes
Gene expression
Medical prognosis
Medical research
Morphology
Rodents
Tumors
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Zusammenfassung:Highlights * STMN4andROBO2gene expression is consistently up-regulated in neuroblastoma cells induced to differentiate. * Ectopic expression of transfectedSTMN4orROBO2induces IMR-32 cells to differentiate, showing a causal link with the differentiated phenotype. * High tumourSTMN4andROBO2mRNA expression is associated with better progression-free survival of neuroblastoma patients.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2012.08.015