Cytosolic cathepsin B initiate acinar cell death through cleavage of bid

Cytosolic cathepsin B initiate acinar cell death through cleavage of bid

In acinar cells from WT mice supramaximal caerulein (0.1μM) stimulation significantly reduced cell viability and increased caspase-3 activity but no increase in caspase 3 activity or cell death was observed in acini from WT mice pretreated with cathepsin B inhibitor CA074me or from cathepsin B or T...

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Veröffentlicht in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2013-03, Vol.13 (2), p.e10-e10
Hauptverfasser: Zhu, H, Talukdar, R, Sundaresan, S, Kumar, S, Dawra, R, Saluja, A
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Endocrinology & Metabolism
Gastroenterology and Hepatology
Pancreas
Rodents
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Zusammenfassung:In acinar cells from WT mice supramaximal caerulein (0.1μM) stimulation significantly reduced cell viability and increased caspase-3 activity but no increase in caspase 3 activity or cell death was observed in acini from WT mice pretreated with cathepsin B inhibitor CA074me or from cathepsin B or T7 knockout mice.
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2012.12.089