Metformin inhibits the TCA cycle and fatty acid synthesis in MIAPaCa-2 pancreatic cancer cells

Metformin inhibits the TCA cycle and fatty acid synthesis in MIAPaCa-2 pancreatic cancer cells

Understanding the mechanism behind the phenotypic differences in metformin's control of metabolic fluxes in these two cell lines will help support the application of metformin as a potential anti-cancer drug and potentially discover novel drug targets for pancreatic cancer.

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Bibliographische Detailangaben
Veröffentlicht in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2013-03, Vol.13 (2), p.e18-e18
Hauptverfasser: Cantoria, M.J, Boros, L.G, Meuillet, E.J
Format: Artikel
Sprache:eng
Schlagworte:
Endocrinology & Metabolism
Gastroenterology and Hepatology
Labeling
Medical research
Metabolism
Pancreatic cancer
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Beschreibung
Zusammenfassung:Understanding the mechanism behind the phenotypic differences in metformin's control of metabolic fluxes in these two cell lines will help support the application of metformin as a potential anti-cancer drug and potentially discover novel drug targets for pancreatic cancer.
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2012.12.115